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首页> 美国卫生研究院文献>Pakistan Journal of Medical Sciences >Factors associated with epileptic seizure of cavernous malformations in the central nervous system in West China
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Factors associated with epileptic seizure of cavernous malformations in the central nervous system in West China

机译：中国西部中枢神经系统海绵状畸形癫痫发作的相关因素

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>Objective: To explore the factors associated with preoperative and postoperative epileptic seizure in patients with cavernous malformations (CMs). >Methods: A total of 52 consecutive patients from January 2009 to June 2011 who underwent surgical treatment in West China Hospital of Sichuan University due to CMs and confirmed by histopathology were retrospectively reviewed.Patients were divided into two groups (epilepsy-group and non-epilepsy group) according to clinical presentation. Other clinical data, treatment procedure, and follow-up information were collected. Engel classification was used to evaluate seizure outcome. >Results: Low birth weight, temporal lobe involvement and cortical lesion showed significant difference between two groups (p=0.017, 0.003 and 0.025 respectively). Cortical lesion highly increased risk for preoperative epileptic seizure (OR=10.48; 95% CI 1.61-68.23). After a mean follow-up of 2.1 years, 77.8% of epileptic patients achieved Engel class I. Temporal lobe involvement, lesion size < 2.5cm and surgery within one year of symptom onset were found associated with better seizure outcome (p=0.016, 0.012 and 0.050). Temporal lobe involvement significantly decreased the risk for postoperative epileptic seizure (OR=0.038; 95% CI 0.002-0.833). Application of ECoG made no significant difference to seizure outcome (p=0.430). Most patients need continuing medication therapy after surgery. >Conclusion: Surgical treatment of patient with CMs is satisfactory in most cases and temporal lobe involvement usually predict favourable postoperative seizure outcome whether under the monitoring of ECoG or not. Thus, epileptic patients with CMs should be considered for surgical treatment especially when cortical brain layer or temporal lobe was involved.
机译：>目的：探讨与海绵状畸形（CMs）患者术前和术后癫痫发作相关的因素。 >方法：回顾性分析2009年1月至2011年6月在四川大学华西医院接受CM手术治疗并经组织病理学证实的52例患者。患者分为两组（癫痫组和非癫痫组）根据临床表现。收集其他临床数据，治疗程序和随访信息。恩格尔分类法用于评估癫痫发作的结果。 >结果：低出生体重，颞叶受累和皮质病变在两组之间有显着差异（分别为p = 0.017、0.003和0.025）。皮质病变大大增加了术前癫痫发作的风险（OR = 10.48； 95％CI 1.61-68.23）。平均随访2.1年后，有77.8％的癫痫患者达到了恩格尔I类。发现颞叶受累，病变尺寸<2.5cm和在症状发作的一年内进行手术与癫痫发作效果更好相关（p = 0.016，0.012和0.050）。颞叶受累可显着降低术后癫痫发作的风险（OR = 0.038； 95％CI 0.002-0.833）。使用ECoG对癫痫发作的结果无显着影响（p = 0.430）。大多数患者术后需要继续药物治疗。 >结论：在大多数情况下，对CMs的手术治疗是令人满意的，并且无论是否在ECoG的监测下，颞叶受累通常可预测术后癫痫发作的良好结局。因此，应考虑对患有CMs的癫痫患者进行手术治疗，尤其是当涉及皮质脑层或颞叶时。

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