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首页> 美国卫生研究院文献>Pharmaceutical Biology >Protective effects of Ficus carica leaves on glucose and lipids levels carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats
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Protective effects of Ficus carica leaves on glucose and lipids levels carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats

机译：榕叶对2型糖尿病大鼠葡萄糖和脂质碳水化合物代谢酶和β细胞的保护作用

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>Context: The decoctions of Ficus carica Linn. (Moraceae) leaves are used in the folklore treatment of diabetes.>Objective: To evaluate the effect of F. carica on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells protective effects in type 2 diabetes.>Material and methods: Diabetes was induced in 15 days high-fat diet (HFD)-fed Wistar rats by intraperitoneal injection of streptozotocin (STZ) (40 mg/kg). The ethyl acetate extract (250 and 500 mg/kg) of F. carica leaves was administered for 28 days. Oral glucose tolerance (OGTT) and intraperitoneal insulin tolerance tests (ITT) were evaluated on 15th and 25th days, respectively.>Results: The ethyl acetate extract (250 and 500 mg/kg) of n F. carica leaves showed significant effect (p < 0.005) in the levels of blood glucose, total cholesterol (TC), triglycerides (TG), body weight and hepatic glycogen. In OGTT, F. carica (250 and 500 mg/kg) significantly (p < 0.005) detained the increase in blood glucose levels at 60 and 120 min and in ITT, F. carica enhanced the glucose utilization significantly (p < 0.005) over 30 and 60 min compared to diabetic control. Further, the altered activities of key carbohydrate metabolizing enzymes such as glucose-6-phosphatase, fructose-1,6-bisphosphatase and hexokinase in the liver tissue of diabetic rats were significantly (p < 0.005) reverted to near normal levels upon treatment with F. carica. Immumohistochemical studies of islets substantiated the cytoprotective effect on pancreatic β-cells.>Discussion and conclusions:F. carica leaves exerted significant effect on carbohydrate metabolism enzymes with promising hypoglycemic and hypolipidemic activities in type 2 diabetic rats.
机译：>上下文：榕榕的汤。 （桑科）树叶用于糖尿病的民间传说治疗。>目的：研究心叶番荔枝对2型糖尿病患者葡萄糖和脂质水平，碳水化合物代谢酶和β细胞保护作用的影响。 >材料和方法：腹腔注射链脲佐菌素（STZ）（40μmg/ kg）在高脂饮食（HFD）喂养的Wistar大鼠中进行15天的糖尿病诱导。给予番木瓜叶乙酸乙酯提取物（250和500μmg/ kg）28天。在第15天和第25天分别评估了口服葡萄糖耐量（OGTT）和腹膜内胰岛素耐量测试（ITT）。>结果： n。Carica的乙酸乙酯提取物（250和500μmg/ kg）叶片对血糖，总胆固醇（TC），甘油三酸酯（TG），体重和肝糖原水平具有显着影响（p <0.005）。在OGTT中，F。carica（250和500μg/ kg）显着（p <0.005）阻止了60和120 levelsmin时血糖水平的增加，而在ITT中，Carica F. carica显着提高了葡萄糖利用率（p <0.005）。与糖尿病对照组相比，分别为30分钟和60分钟。此外，用F处理后，糖尿病大鼠肝脏组织中关键的碳水化合物代谢酶（如葡萄糖-6-磷酸酶，果糖-1,6-双磷酸酶和己糖激酶）的活性变化显着（p <0.005）恢复到接近正常水平。卡里卡胰岛的免疫组织化学研究证实了其对胰腺β细胞的细胞保护作用。>讨论和结论： F。番石榴叶对2型糖尿病大鼠的碳水化合物代谢酶具有显着的降血糖和降血脂活性，具有显着影响。

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