From plant extract to molecular panacea: a commentary on Stone (1763) ‘An account of the success of the bark of the willow in the cure of the agues’

机译：从植物提取物到分子灵丹妙药：对斯通（1763）的评论柳树皮在治愈海牙方面的成功之道

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The application of aspirin-like drugs in modern medicine is very broad, encompassing the treatment of inflammation, pain and a variety of cardiovascular conditions. Although anecdotal accounts of willow bark extract as an anti-inflammatory drug have occurred since written records began (for example by Hippocrates), the first convincing demonstration of a potent anti-pyretic effect of willow bark containing salicylates was made by the English cleric Edward Stone in the late eighteenth century. Here, we discuss the route to optimizing and understanding the mechanism of action of anti-inflammatory drugs that have their origins in Stone's seminal study, ‘An account of the success of the bark of the willow in the cure of agues’. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

机译：类阿司匹林药物在现代医学中的应用非常广泛，涵盖了炎症，疼痛和各种心血管疾病的治疗。尽管自书面记录开始（例如，希波克拉底）以来就已经有柳树皮提取物作为消炎药的传闻（英语），但英国牧师爱德华•斯通（Edward Stone）首次证明了含有水杨酸酯的柳树皮具有有效的解热作用。在十八世纪末。在这里，我们讨论了优化和了解抗炎药的作用机理的途径，这些抗炎药的起源来自Stone的开创性研究，“柳树皮在治愈黑头病方面的成功之道”。这篇评论是为庆祝《皇家学会哲学交易》发表350周年而写的。

著录项

期刊名称 Philosophical Transactions of the Royal Society B: Biological Sciences
作者
John N. Wood;
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作者单位

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年(卷),期 2015(370),1666
年度 2015
页码 20140317
总页数 6
原文格式 PDF
正文语种
中图分类生物学;
关键词
pain inflammation malaria fever cardiovascular function aspirin;

机译：疼痛;炎症;疟疾;发烧;心血管功能;阿司匹林;

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专利

1. From plant extract to molecular panacea: a commentary on Stone (1763) 'An account of the success of the bark of the willow in the cure of the agues' [J] . Wood John N. Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences . 2015,第1666期

机译：从植物提取物到分子灵丹妙药：对斯通（1763）的评论“关于柳树皮成功治愈黑头病的报道”
2. Samuel James (c1763–1831) of Hoddesdon and the medicinal use of willow bark [J] . William S Pierpoint Journal of Medical Biography . 2007,第1期

机译：Hoddesdon的Samuel James（c1763-1831）和柳树皮的药用
3. Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants [J] . Sadeer Nabeelah Bibi, Jose Llorent-Martinez Eulogio, Bene Kouadio, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2019,第期

机译：三种非洲药用植物的叶片和茎树皮提取物的化学分析，抗氧化剂，酶抑制和分子建模研究
4. Study of Efficacy and Safety of Willow Bark Extract (Assalix) in Treatment of Chronic Low Back Pain in Patients of Different Age with Osteochondrosis [C] . V.V. Povoroznyuk, T.A. Karasevskaya International Pain Clinic Congress . 2008

机译：柳树皮提取物（Assalix）治疗不同年龄患者慢性低腰疼痛的疗效和安全性研究
5. Part 1 Screening of Thirty One Medicinal Plant Species Against Herpes Simplex Virus: Acetone and Methanol Extracts From The Root Tissue Of Kalanchoe Pinnata Interferes With HSV Types 1 and 2 DNA Replication and Early and Late Gene Expression Preventing the Spread of HSV In Vitro Part 2 Professional Development Curriculum: Integrating Molecular Biology and Microbiology Into the Existing Secondary Biology Curricula. [D] . Greer, Mary Ruth Jaeger. 2009

机译：第1部分针对单纯疱疹病毒的31种药用植物的筛选：羽扇豆根组织中的丙酮和甲醇提取物干扰HSV类型1和2的DNA复制以及早期和晚期基因表达阻止HSV的体外传播第2部分专业人士开发课程：将分子生物学和微生物学整合到现有的中学生物学课程中。
6. Observations on the Superior Efficacy of the Red Peruvian Bark in the Cure of Agues and Other Fevers. Interspersed with Occasional Remarks on the Treatment of Other Diseases by the Same Remedy [O] . 1782

机译：在Agues和其他发烧的治愈中观察红色秘鲁树皮的超强功效。通过相同的疗法穿插偶尔对其他疾病的治疗
7. Organosolv delignification of residual plantation willow bark after extractive removal [O] . Matiss Pals, Liga Lauberte, Alexandr Arshanitsa, 2020

机译：诱导脱落后残留种植率柳树皮的有机溶胶脱落

From plant extract to molecular panacea: a commentary on Stone (1763) ‘An account of the success of the bark of the willow in the cure of the agues’

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