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首页> 美国卫生研究院文献>Polymers >Wound Dressings Based on Chitosan-Dialdehyde Cellulose Nanocrystals-Silver Nanoparticles: Mechanical Strength Antibacterial Activity and Cytotoxicity
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Wound Dressings Based on Chitosan-Dialdehyde Cellulose Nanocrystals-Silver Nanoparticles: Mechanical Strength Antibacterial Activity and Cytotoxicity

机译：基于壳聚糖-二醛纤维素纳米晶体-银纳米颗粒的伤口敷料：机械强度抗菌活性和细胞毒性

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摘要

The present work envisages a simple approach to synthesize a new wound dressing based on chitosan-dialdehyde cellulose nanocrystal-silver nanoparticles (CS-DCNC-AgNPs). Silver nanoparticles (AgNPs) were generated in-situ by periodate oxidation of cellulose nanocrystals to generate aldehyde functions, which were used to reduce Ag+ into Ag0 in mild alkaline conditions. Subsequently, the dialdehyde cellulose nanocrystal-silver nanoparticles (DCNC-AgNPs) were added to chitosan (CS) to form the wound dressings by solution casting method. The aim was to enhance the antibacterial effect of CS by incorporation of AgNPs and to improve the mechanical strength and hydrophobicity of CS by incorporation of DCNC that cross-linked by hydrogen bonds. The antibacterial activities were evaluated against five gram-negative bacteria, one gram-positive bacteria, and three fungi. The in vitro cytotoxicity assay was performed using the NIH3T3 cell lines by Sulforhodamine B assay. Research outputs signified that CS-DCNC-AgNPs possessed good mechanical strength and hydrophobicity, high antibacterial activity and less cytotoxicity. Our results propose that CS-DCNC-AgNPs can be a promising, safe antibacterial to be incorporated in wound dressings.
机译：本工作设想了一种基于壳聚糖-二醛纤维素纳米晶体-银纳米颗粒（CS-DCNC-AgNPs）合成新伤口敷料的简单方法。通过对纤维素纳米晶体的高碘酸盐进行过氧化氧化原位生成银纳米颗粒（AgNPs），以产生醛官能团，然后在温和的碱性条件下将Ag + 还原为Ag 0 。随后，将二醛纤维素纳米晶体-银纳米颗粒（DCNC-AgNPs）添加到壳聚糖（CS）中以通过溶液流延法形成伤口敷料。目的是通过掺入AgNP来增强CS的抗菌作用，并通过掺入通过氢键交联的DCNC来改善CS的机械强度和疏水性。评价了对5种革兰氏阴性菌，1种革兰氏阳性菌和3种真菌的抗菌活性。使用NIH3T3细胞系通过磺胺多巴胺B测定进行体外细胞毒性测定。研究结果表明，CS-DCNC-AgNPs具有良好的机械强度和疏水性，较高的抗菌活性和较低的细胞毒性。我们的研究结果表明，CS-DCNC-AgNPs是一种有前途的，安全的抗菌药物，可用于伤口敷料中。

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