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Biomedical Grade Stainless Steel Coating of Polycaffeic Acid via Combined Oxidative and Ultraviolet Light-Assisted Polymerization Process for Bioactive Implant Application

机译:通过生物活性植入物的组合氧化和紫外光辅助聚合工艺对聚咖啡酸的生物医学级不锈钢涂层

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摘要

Stainless steel as a biomedical implant material has been studied in various fields and in various forms, such as vascular stents, bone plates, dental screws, and artificial hip and bone material. In this study, we used polycaffeic acid (PCA), a natural phenolic compound, to coat the surface of medical grade stainless steel to provide added potential medicinal effects by virtue of its inherent anti-inflammatory, antiviral, antifibrosis, antithrombosis, and antihypertensive characteristics. We did this via UV irradiation under an alkaline state to solve the cost and time problems of other existing coating methods. The physicochemical properties of the samples were investigated through field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), contact angle, FTIR, and X-ray photoelectron spectroscopy (XPS). Surface bioactivity using NIH-3T3 cell lines were observed in vitro. We expect that the proposed methodology may contribute to the field of study of implantable metallic devices.
机译:作为生物医学植入物材料的不锈钢已经在各个领域以各种形式进行了研究,例如血管支架,骨板,牙螺钉以及人工髋和骨材料。在这项研究中,我们使用天然酚类化合物聚咖啡酸(PCA)覆盖医用级不锈钢的表面,以其固有的抗炎,抗病毒,抗纤维化,抗血栓形成和抗高血压的特性,从而提供潜在的药用效果。 。我们通过在碱性状态下进行紫外线照射来解决此问题,以解决其他现有涂覆方法的成本和时间问题。通过场发射扫描电子显微镜(FESEM),原子力显微镜(AFM),接触角,FTIR和X射线光电子能谱(XPS)研究了样品的理化性质。在体外观察到使用NIH-3T3细胞系的表面生物活性。我们希望所提出的方法可能有助于可植入金属装置的研究领域。

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