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Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering

机译：工程化的电纺聚氨酯复合膜与双功能成分相结合可为心脏组织工程提供高强度

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Cardiovascular application of nanomaterial’s is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO2) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Fourier transform infrared spectroscopy results showed the interaction of the pristine polymer with the added substances. Thermal analysis showed the increased onset degradation, whereas the mechanical testing portrayed the increased tensile strength of the composites. Finally, the composite delayed the coagulation times and also rendered safe environment for red blood cells signifying its suitability to be used in contact with blood. Strikingly, the cellular toxicity of the developed composite was lower than the pristine polymer suggesting its compatible nature with the surrounding tissues. With these promising characteristics, developed material with enhanced physicochemical properties and blood compatibility can be successfully utilized for cardiac tissue applications.
机译：纳米材料在心血管领域的需求日益增长，其使用受到机械和血液相容性的限制。在这项工作中，尝试开发一种负载有罗勒油和二氧化钛（TiO2）颗粒的新型电纺纳米复合材料。与原始聚合物相比，复合材料的疏水性增加，纤维直径减小。傅里叶变换红外光谱结果表明，原始聚合物与添加的物质相互作用。热分析表明开始降解的增加，而机械测试表明复合材料的拉伸强度增加。最终，该复合物延迟了凝血时间，还为红细胞提供了安全的环境，表明它适合与血液接触。令人惊讶的是，开发的复合材料的细胞毒性低于原始聚合物，表明其与周围组织的相容性。具有这些令人鼓舞的特性，具有增强的物理化学性质和血液相容性的开发材料可以成功地用于心脏组织应用。

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