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首页> 美国卫生研究院文献>Polymers >Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation
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Polylactide Composite Pins Reinforced with Bioresorbable Continuous Glass Fibers Demonstrating Bone-like Apatite Formation and Spiral Delamination Degradation

机译：生物可吸收的连续玻璃纤维增​​强的聚乳酸复合材料销钉显示出骨样磷灰石的形成和螺旋分层的降解。

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The emergence of polylactide composites reinforced with bioresorbable silicate glass fibers has allowed for the long-term success of biodegradable polymers in load-bearing orthopedic applications. However, few studies have reported on the degradation behavior and bioactivity of such biocomposites. The aim of this work was to investigate the degradation behavior and in vitro bioactivity of a novel biocomposite pin composed of bioresorbable continuous glass fibers and poly-L-D-lactide in simulated body fluid for 78 weeks. As the materials degraded, periodic spiral delamination formed microtubes and funnel-shaped structures in the biocomposite pins. It was speculated that the direction of degradation, from both ends towards the middle of the fibers and from the surface through to the bulk of the polymer matrix, could facilitate bone healing. Following immersion in simulated body fluid, a bone-like apatite layer formed on the biocomposite pins which had a similar composition and structure to natural bone. The sheet- and needle-like apatite nanostructure was doped with sodium, magnesium, and carbonate ions, which acted to lower the Ca/P atomic ratio to less than the stoichiometric apatite and presented a calcium-deficient apatite with low crystallinity. These findings demonstrated the bioactivity of the new biocomposite pins in vitro and their excellent potential for load-bearing applications.
机译：用可生物吸收的硅酸盐玻璃纤维增​​强的聚丙交酯复合材料的出现使可生物降解的聚合物在承重的骨科应用中取得了长期的成功。然而，很少有研究报道这种生物复合材料的降解行为和生物活性。这项工作的目的是研究一种新型的生物复合材料针的降解行为和体外生物活性，该材料由可生物吸收的连续玻璃纤维和聚L-D-丙交酯组成，在模拟体液中作用了78周。随着材料的降解，周期性的螺旋分层会在生物复合材料针中形成微管和漏斗形结构。据推测，降解的方向，从两端到纤维的中间，从表面到整个聚合物基质，都可以促进骨愈合。浸入模拟体液后，在生物复合材料针上形成了类似于天然骨骼的骨状磷灰石层。片状和针状磷灰石纳米结构掺杂有钠，镁和碳酸盐离子，其作用是将Ca / P原子比降低到低于化学计量的磷灰石，并呈现出低结晶度的缺钙磷灰石。这些发现证明了新型生物复合材料销的体外生物活性及其在承重应用中的出色潜力。

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