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首页> 美国卫生研究院文献>Postgraduate Medical Journal >The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers.
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The impact of a short course of three lipid lowering drugs on fat oxidation during exercise in healthy volunteers.

机译：短期服用三种降脂药对健康志愿者运动过程中脂肪氧化的影响。

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We examined the impact of three lipid lowering drugs on fat oxidation during a 120 minute treadmill walk, at an exercise intensity of 50% maximal oxygen uptake (VO2 max). Subjects (N = 24) were healthy male volunteers with normal serum chemistry, assigned to three groups (n = 8). Group A received simvastatin 20 mg twice daily, Group B received gemfibrozil 600 mg twice daily, Group C received acipimox 600 mg twice daily. Each subject performed two 120 minute walks, once with drug, and once with placebo (4 days treatment plus a final dose on the morning of the exercise trial). Treatment order was reversed for half of each group. Compared to placebo, simvastatin treatment, had no impact on fat oxidation (40.9 +/- 8.6% vs 40.9 +/- 9.7%), or on plasma concentration of free fatty acids (FFA), glycerol or glucose. Treatment with gemfibrozil, showed lower fat oxidation (32.3 +/- 13.9% vs 39.7 +/- 7.9%), and lower plasma concentrations of FFA and glycerol, but differences did not reach significance at the 0.05 level. Acipimox treatment, produced significantly lower fat oxidation (36.9 +/- 12.8% vs 50.2 +/- 16.1%, P = 0.011), and lower plasma concentrations of FFA and glycerol (P = < 0.0001 and P = < 0.0001, respectively). Plasma glucose showed a trend toward lower values with acipimox (P = 0.088). These data demonstrate that selective lipid lowering drugs can reduce fat availability for exercise metabolism, placing increased demands on carbohydrates which may reduce exercise tolerance.
机译：我们在120分钟的跑步机步行中，以最大摄氧量50％（VO2 max）的运动强度，研究了三种降脂药物对脂肪氧化的影响。受试者（N = 24）是血清化学指标正常的健康男性志愿者，分为三组（n = 8）。 A组每天两次接受辛伐他汀20 mg，B组每天两次接受吉非贝齐600 mg，C组每天两次接受acipimox 600 mg。每个受试者进行两次120分钟的步行，一次用药物，一次用安慰剂（4天治疗，并在运动试验的早晨服用最终剂量）。每组一半的治疗顺序相反。与安慰剂相比，辛伐他汀治疗对脂肪氧化（40.9 +/- 8.6％与40.9 +/- 9.7％）或游离脂肪酸（FFA），甘油或葡萄糖的血浆浓度没有影响。吉非贝齐治疗显示较低的脂肪氧化（32.3 +/- 13.9％比39.7 +/- 7.9％），以及较低的FFA和甘油血浆浓度，但在0.05水平上差异不显着。 Acipimox处理产生的脂肪氧化显着降低（36.9 +/- 12.8％与50.2 +/- 16.1％，P = 0.011），以及较低的FFA和甘油血浆浓度（分别为P = <0.0001和P = <0.0001）。血浆中阿昔莫司的血糖值呈降低趋势（P = 0.088）。这些数据表明选择性降脂药物可以减少运动代谢的脂肪利用率，对碳水化合物的需求增加，这可能会降低运动耐力。

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