首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction
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Cells Involved in Cell-Mediated and Transplantation Immunity in the Rabbit I. The Noninvolvement of the Bone Marrow Antigen Reactive Cell in the Transplant Rejection Reaction

机译:参与细胞介导和移植免疫的细胞I。移植排斥反应中不涉及骨髓抗原反应性细胞

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摘要

Rabbits were subjected to 800 r total body irradiation to render them immunoincopetent with respect to the humoral immune response. These rabbits were, however, only slightly less capable of rejecting skin allografts than nonirradiated rabbits. Furthermore, the administration of normal or specifically „primed” bone marrow cells (bone marrow obtained from a rabbit injected one to two days previously with the spleen cells obtained from the prospective skin donor) did not enhance or inhibit the graft rejection reaction. It is concluded that the cells mediating the humoral immune response are different from those mediating the cellular immune response.
机译:对兔子进行800 r全身照射,使其在体液免疫反应方面无免疫能力。但是,这些兔子拒绝同种异体皮肤的能力仅比未辐照兔子低。此外,正常或特定的“初免”骨髓细胞(从一到两天前注射了从预期皮肤供体获得的脾细胞注射的兔子获得的骨髓)的给药并未增强或抑制移植排斥反应。结论是介导体液免疫应答的细胞不同于介导细胞免疫应答的细胞。

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