• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Increased concentrations of nonesterified arachidonic acid 12L-hydroxy-581014-eicosatetraenoic acid prostaglandin E2 and prostaglandin F2alpha in epidermis of psoriasis.
【2h】

Increased concentrations of nonesterified arachidonic acid 12L-hydroxy-581014-eicosatetraenoic acid prostaglandin E2 and prostaglandin F2alpha in epidermis of psoriasis.

机译：牛皮癣表皮中非酯化花生四烯酸12L-羟基-581014-二十碳四烯酸前列腺素E2和前列腺素F2alpha的浓度增加。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lesional epidermis of psoriasis has a probable reduction in the cyclic AMP/cyclic GMP ratio. This altered ratio may in part be responsible for the characteristic glycogen storage, rapid cell proliferation, and reduced differentiation in lesional epidermis. The concentrations of prostaglandins E2 and F2alpha, free arachidonic acid, and 12L-hydroxy-5,8,10,14-eicosatetrawnoic acid in specimens of uninvolved and involved epidermis of psoriasis were measured with deuterium-labeled carriers and multiple ion analysis. Snap frozen specimens contained: 1.4 +/- 0.4 mug/g (wet weight) of arachidonic acid in uninvolved in contrast to 36.3 +/- 16.7 mug/g in involved epidermis (P = 0.015); less than 0.05 +/- 0.01 mug/g of hydroxyeicosatetraenoic acid in uninvolved in contrast to 4.1 +/- 1.9 mug/g in involved epidermis (P = 0.015); 23.6 +/- 5.0 ng/g of prostaglandin E2 in uninvolved in contrast to 33.1 +/- 5.7 ng/g in involved epidermis (P less than 0.01); and 21.0 +/- 4.4 ng/g of prostaglandin F2alpha in uninvolved in contrast to 39.0 +/- 5.9 ng/g in involved epidermis (P less than 0.01). The arachidonic acid and hydroxyeicosatetraenoic acid levels in involved epidermis were strongly correlated (r = 0.97). The increased levels of arachidonic acid and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid in involved epidermis may have diagnostic and pathophysiological importance.
机译：牛皮癣的病灶表皮可能会降低循环AMP /循环GMP比率。这种变化的比例可能部分负责特征性糖原的储存，细胞的快速增殖以及病灶表皮的分化减少。用氘标记的载体和多重离子分析法测定了牛皮癣的未累及受累表皮中前列腺素E2和F2α，游离花生四烯酸和12L-羟基-5,8,10,14-二十碳四烯酸的浓度。速冻样品中含有：不参与的花生四烯酸为1.4 +/- 0.4杯/克（湿重），而涉及的表皮为36.3 +/- 16.7杯/克（P = 0.015）；少于0.05 +/- 0.01杯/克的羟基二十碳四烯酸，而涉及的表皮为4.1 +/- 1.9杯/克（P = 0.015）； 23.6 +/- 5.0 ng / g的前列腺素E2不参与，而表皮受累的前列腺素E2为33.1 +/- 5.7 ng / g（P小于0.01）；和21.0 +/- 4.4 ng / g的前列腺素F2alpha无关，而受累表皮则为39.0 +/- 5.9 ng / g（P小于0.01）。涉及表皮中的花生四烯酸和羟基二十碳四烯酸水平高度相关（r = 0.97）。受累表皮中花生四烯酸和12L-羟基-5,8,10,14-二十碳四烯酸水平的升高可能具有诊断和病理生理意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号