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首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >High blood pressure related to carcinogen-induced unscheduled DNA synthesis DNA carcinogen binding and chromosomal aberrations in human lymphocytes.
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High blood pressure related to carcinogen-induced unscheduled DNA synthesis DNA carcinogen binding and chromosomal aberrations in human lymphocytes.

机译：高血压与致癌物诱导的计划外DNA合成DNA致癌物结合以及人类淋巴细胞中的染色体畸变有关。

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摘要

Unscheduled DNA synthesis (excision-repair) of N-acetoxy-2-acetylaminofluorene (NA-AAF) damage to the DNA of human lymphocytes was determined quantitatively for 92 individuals with diastolic blood pressures ranging from 65 to 120 mm of Hg (8,7 to 16 kPa). Measurements of NA-AAF-induced repair synthesis (incorporation of[3H]thymidine in the presence of 10 mM hydroxyurea) showed linear increase with the blood pressure in the individuals under study. Concurrent determinations for the levels of 3H-labeled 7,12-dimethyl-benz[a]anthracene bound to the DNAs of lymphocytes after 18 hr of culturing have shown that increased amounts of DNA bound carcinogen were linearly proportional to increased NA-AAF-induced repair synthesis values, and therefore were correlated to high blood pressure. The number of NA-AAF-induced chromosomal abberations in lymphocytes increased linearly with the diastolic blood pressures of the individuals. High NA-AAF-induced repair synthesis values also tended to be associated with increased NA-AAF-induced chromosomal damage. Together, these results suggest that individuals with elevated blood pressures have a greater potential for accumulating DNA damage, because of an increased chemical reactivity of lymphocytes to carcinogen exposure, than do individuals with normal blood pressure.
机译：定量确定了舒张压范围从65到120毫米汞柱的92个人的N-乙酰氧基-2-乙酰氨基芴（NA-AAF）对人淋巴细胞DNA的计划外DNA合成（切除修复）至16 kPa）。 NA-AAF诱导的修复合成（在10 mM羟基脲存在下[3H]胸苷的掺入）的测量结果显示，该个体的血压随血压呈线性增加。培养18小时后，同时测定3H标记的7,12-二甲基-苯并[a]蒽与淋巴细胞DNA结合的水平表明，DNA结合致癌物的增加与NA-AAF诱导的增加成线性比例关系。修复合成值，因此与高血压相关。淋巴细胞中NA-AAF诱导的染色体畸变的数量随着个体舒张压的增加而线性增加。高NA-AAF诱导的修复合成值也往往与NA-AAF诱导的染色体损伤增加有关。总之，这些结果表明，与正常血压的人相比，血压升高的人由于淋巴细胞对致癌物的化学反应增加而具有更大的累积DNA损伤的潜力。

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