Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

机译：如单克隆抗体所揭示对抗药性肿瘤细胞特异的170至180 kDa糖蛋白的功能作用。

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摘要

An overexpression of the plasma membrane glycoprotein of relative molecular size 170-180 kDa is consistently found in different multidrug-resistant human and animal cell lines, although the functional role of the protein in multidrug resistance is not known. Two monoclonal antibodies that interfere with biochemical functions were generated against the human myelogenous leukemia K-562 cells resistant to adriamycin (K-562/ADM). These antibodies, designated MRK16 and MRK17, are specifically reactive to K-562/ADM and a human ovarian cancer cell line resistant to adriamycin (2780AD). MRK16 modulated vincristine and actinomycin D transport in the resistant cells, while MRK17 specifically inhibited the growth of the resistant cells. Both antibodies recognized the 170- to 180-kDa glycoprotein. These data indicate that the 170- to 180-kDa glycoprotein is involved, directly or indirectly, in the drug transport mechanisms and the proliferation of multidrug-resistant tumor cell lines.

机译：在不同的耐多药的人和动物细胞系中始终发现相对分子大小为170-180 kDa的质膜糖蛋白的过表达，尽管该蛋白在耐多药性中的功能作用尚不清楚。针对人对阿霉素（K-562 / ADM）的骨髓性白血病K-562细胞产生了两种干扰生化功能的单克隆抗体。这些称为MRK16和MRK17的抗体对K-562 / ADM和对阿霉素（2780AD）有抗性的人卵巢癌细胞系具有特异性反应。 MRK16调节了耐药细胞中长春新碱和放线菌素D的转运，而MRK17特异性抑制了耐药细胞的生长。两种抗体都识别170-180kDa的糖蛋白。这些数据表明170-180kDa的糖蛋白直接或间接地参与了药物转运机制和多药耐药肿瘤细胞系的增殖。

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
H Hamada; T Tsuruo;
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年(卷),期 1986(83),20
年度 1986
页码 7785–7789
总页数 5
原文格式 PDF
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机译：针对阶段特异性胎儿脑68-kDa糖蛋白（FGP68）的单克隆抗体揭示了人类原发性脑肿瘤中FGP68表达的增加
2. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. [J] . H M Cherwinski, J H Schumacher, K D Brown, The Journal of Experomental Medicine . 1987,第5期

机译：两种类型的小鼠辅助T细胞克隆。三， RNA杂交，功能性单特异性生物测定和单克隆抗体揭示了Th1和Th2克隆之间淋巴因子合成的进一步差异。
3. Specific thermal ablation of tumor cells using single-walled carbon nanotubes targeted by covalently-coupled monoclonal antibodies. [J] . Marches R, Chakravarty P, Musselman I International Journal of Cancer =: Journal International du Cancer . 2009,第12期

机译：使用被共价偶联的单克隆抗体靶向的单壁碳纳米管对肿瘤细胞进行特异性热消融。
4. Effect of anti-P-glycoprotein monoclonal antibody on Tc-99m -MIBI uptake in tumor cells and the drug sensitivity in tumor cells [C] . The First China-Japan-Korea conference of nuclear medicine . 2002

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5. The role of natural killer cells in the response to anti-tumor antibodies. [D] . Roda, Julie M. 2007

机译：天然杀伤细胞在抗肿瘤抗体反应中的作用。
6. Role of complement and the Fc portion of immunoglobulin G in immunity to Venezuelan equine encephalomyelitis virus infection with glycoprotein-specific monoclonal antibodies. [O] . J H Mathews, J T Roehrig, D W Trent 1985

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7. Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. [O] . Hamada, H, Tsuruo, T 1986

机译：如单克隆抗体所揭示，对抗药性肿瘤细胞特异的170至180 kDa糖蛋白的功能作用。
8. Mouse Monoclonal Antibody Specific for an Allotypic Determinant of the Igh(a) Allele of Murine IgM: Genetic and Functional Analysis of Igh-6a Epitopes Using Anti-IgM Monoclonal Antibodies. [R] . Sieckmann, D. G., Stall, A. M., Subbarao, B. 1991

机译：小鼠单克隆抗体特异性针对Igh（a）小鼠Igm等位基因的同种型决定因素：使用抗Igm单克隆抗体的Igh-6a表位的遗传和功能分析。

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

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