Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients.

机译：在海马CA3锥体细胞中缓慢的Ca2（+）激活钾电导的毒蕈碱和β-肾上腺素的抑制不是由去极化诱导的胞质Ca2 +瞬变的减少介导的。

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Combined intracellular and microfluorometric recording techniques were used to evaluate whether the inhibition by cholinergic or adrenergic transmitters of the Ca2(+)-activated potassium current (IAHP) in hippocampal CA3 pyramidal cells was mediated by an alteration of depolarization-induced change in cytosolic free Ca2+ concentration [(Ca2+]i). Low concentrations of isoproterenol (1-10 microM) and muscarine (0.25-1 microM) reversibly abolished IAHP without affecting concomitant Ca2+ transients or the steady-state [Ca2+]i. Only after application of higher concentrations of muscarine, [Ca2+]i increased; in the presence of potassium channel blockers, muscarine depressed Ca2+ currents and concomitant Ca2+ transients. These observations provide direct evidence that the inhibition of IAHP by isoproterenol and muscarine are not mediated by an alteration of Ca2+ dynamics.

机译：结合细胞内和微荧光记录技术来评估海马CA3锥体细胞中Ca2（+）激活的钾电流（IAHP）的胆碱能或肾上腺素递质的抑制是否是由去极化诱导的胞质游离Ca2 +改变的改变介导的浓度[（Ca2 +] i）。低浓度的异丙肾上腺素（1-10 microM）和毒蕈碱（0.25-1 microM）可逆地废除IAHP，而不会影响伴随的Ca2 +瞬变或稳态[Ca2 +] i。仅在施用较高浓度的毒蕈碱后，[Ca2 +] i升高；在钾通道阻滞剂的存在下，毒蕈碱抑制了Ca2 +电流并伴随着Ca2 +瞬变。这些观察结果提供直接证据，表明异丙肾上腺素和毒蕈碱对IAHP的抑制作用不是由Ca2 +动力学的改变介导的。

著录项

期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
T Knöpfel; I Vranesic; B H Gähwiler; D A Brown;
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年(卷),期 1990(87),11
年度 1990
页码 4083–4087
总页数 5
原文格式 PDF
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外文文献

1. Muscarinic receptor stimulation reduces NMDA responses in CA3 hippocampal pyramidal cells via Ca2+-dependent activation of tyrosine phosphatase. [J] . Grishin AA, Benquet P, Gerber U Neuropharmacology . 2005,第3期

机译：毒蕈碱受体刺激通过酪氨酸磷酸酶的Ca2 +依赖性活化，降低CA3海马锥体细胞的NMDA反应。
2. Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors. [J] . Rouse ST, Hamilton SE, Potter LT, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第1a2期

机译：毒蕈碱诱导的钾电导调节在缺乏功能性M1受体的小鼠海马锥体细胞中没有改变。
3. L-Type Ca2+ channels mediate the slow Ca2+-dependent afterhyperpolarization current in rat CA3 pyramidal cells in vitro. [J] . Tanabe M, Gahwiler BH, Gerber U Journal of Neurophysiology . 1998,第5期

机译：L型Ca2 +通道介导大鼠CA3锥体细胞中缓慢的Ca2 +依赖性超极化后电流。
4. Modulation of calcium-activated potassium currents in hippocampal pyramidal cells [D] . Taylor, Ruth Doreen Theresa. 2008

机译：钙激活钾电流在海马金字塔型细胞中的调节
5. Emergence of a spermine-sensitive non-inactivating conductance in mature hippocampal CA1 pyramidal neurons upon reduction of extracellular Ca2+: dependence on intracellular Mg2+ and ATP. [O] . Christos Chinopoulos, John A Connor, C William Shuttleworth -1

机译：细胞内Ca2 +减少后成熟海马CA1锥体神经元中精胺敏感非灭活电导的出现：依赖于细胞内Mg2 +和ATP。
6. Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients. [O] . Knöpfel, T, Vranesic, I, Gähwiler, B H, 1990

机译：在海马CA3锥体细胞中，缓慢的Ca2（+）激活钾电导的毒蕈碱和β-肾上腺素抑制不是由去极化诱导的胞质Ca2 +瞬变的减少所介导的。

Muscarinic and beta-adrenergic depression of the slow Ca2(+)-activated potassium conductance in hippocampal CA3 pyramidal cells is not mediated by a reduction of depolarization-induced cytosolic Ca2+ transients.

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