Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.

机译：坏死（sf）小鼠中的致命性淋巴网状疾病需要在sf胸腺环境中成熟的T细胞：胸腺教育的潜在模型。

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Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age. The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated. Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG. Animals bred to be nude and scurfy (nuu; sf/Y) are viable, fertile, and free of scurfy lesions. Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease. We conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.

机译：X连锁突变血吸虫（sf）的半纯合或纯合小鼠的特征性病变包括皮肤和淋巴器官的淋巴组织细胞增生，库姆氏测试阳性贫血，高血球蛋白血症和24天龄死亡。考察了胸腺在毛茸茸的小鼠致命性淋巴网状疾病发展中的作用。尽管持续存在高水平的血清IgG，新生儿胸腺切除术可以使水肿小鼠的寿命延长一倍，减轻组织学损伤并预防贫血。裸露和坏血病（nu / nu; sf / Y）饲养的动物是活的，可育的，并且没有坏血病性病变。坏血病小鼠的骨髓可以重建经致死性辐射的H-2兼容动物，但不会传播坏血病。从这些数据我们可以得出结论，毛骨悚然的病变是由在异常胸腺环境中成熟的T淋巴细胞介导的。

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
V L Godfrey; J E Wilkinson; E M Rinchik; L B Russell;
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年(卷),期 1991(88),13
年度 1991
页码 5528–5532
总页数 5
原文格式 PDF
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5. Formation of functional selectin ligands on activated T cells and thymic progenitors: The role of core 2 beta1,6-N-acetylglucosaminyltransferases in the control of lymphocyte trafficking and thymic progenitor homing. [D] . Merzaban, Jasmeen Sayed. 2005

机译：在激活的T细胞和胸腺祖细胞上形成功能性选择素配体：核心2 beta1,6-N-乙酰氨基葡萄糖氨基转移酶在控制淋巴细胞运输和胸腺祖细胞归巢中的作用。
6. Transplantation of T cell-mediated lymphoreticular disease from the scurfy (sf) mouse. [O] . V. L. Godfrey, B. T. Rouse, J. E. Wilkinson 1994

机译：从坏血病（sf）小鼠移植T细胞介导的淋巴网状疾病。
7. Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education. [O] . Godfrey, V L, Wilkinson, J E, Rinchik, E M, 1991

机译：坏死（sf）小鼠中的致命性淋巴网状疾病需要在sf胸腺环境中成熟的T细胞：胸腺教育的潜在模型。
8. Role of Accessory Cells in B Cell Activation. IV. IA(+) Accessory Cells are Required for the in Vitro Generation of Thymic Independent Type 2 Antibody Responses to Polysaccharide Antigens [R] . Morrissey, P. J., Boswell, H. S., Scher, I., 1981

机译：辅助细胞在B细胞活化中的作用。 IV。 Ia（+）辅助细胞是体外产生胸腺独立2型抗体对多糖抗原的反应所必需的

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.

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