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首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Evolution of gene networks by gene duplications: a mathematical model and its implications on genome organization.
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Evolution of gene networks by gene duplications: a mathematical model and its implications on genome organization.

机译：通过基因重复进行的基因网络进化：一个数学模型及其对基因组组织的影响。

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摘要

Networks of transcriptional regulators have key roles in metazoan development. Important forces in the evolution of these networks are gene duplications and gene deletions, events that may change the spatiotemporal expression pattern of network genes. A measure for the probability of such changes after gene-duplication events is proposed. This measure is based on a simple mathematical model that describes such networks as dynamical systems and on properties of ensembles of these dynamical systems. It is predicted that this probability depends only on the fraction of genes duplicated in a single event and that it is largest if approximately 40% of the genes in a network are duplicated. This property is robust with respect to variations in model parameters. On these grounds, it is argued that (i) evolution of gene networks should preferentially occur either by duplication of single genes or by duplication of all genes involved in a network, and that (ii) tight linkage ("clustering") or strong dispersal are the two evolutionarily most favorable forms of genomic organization of genes forming such networks.
机译：转录调节因子网络在后生动物发育中起关键作用。这些网络进化的重要力量是基因重复和基因缺失，这些事件可能会改变网络基因的时空表达模式。提出了一种在基因复制事件后发生此类变化的概率的措施。此度量基于一个简单的数学模型，该模型描述了诸如动力系统之类的网络，并基于这些动力系统的集合体的属性。据预测，这种可能性仅取决于在单个事件中复制的基因的比例，并且如果网络中大约40％的基因被复制，则该可能性最大。对于模型参数的变化，此属性是可靠的。基于这些理由，有人认为（i）基因网络的进化应优先通过单个基因的复制或网络中涉及的所有基因的复制而发生，以及（ii）紧密的连接（“聚类”）或强烈的分散是形成这种网络的基因的基因组组织的两种进化上最有利的形式。

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