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Ultradeep Pyrosequencing Detects Complex Patterns of CD8+ T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques

机译：超深焦测序技术在猿猴免疫缺陷病毒感染的猕猴中检测到CD8 + T淋巴细胞逃逸的复杂模式。

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摘要

Human and simian immunodeficiency viruses (HIV/SIV) exhibit enormous sequence heterogeneity within each infected host. Here, we use ultradeep pyrosequencing to create a comprehensive picture of CD8⁺ T-lymphocyte (CD8-TL) escape in SIV-infected macaques, revealing a previously undetected complex pattern of viral variants. This increased sensitivity enabled the detection of acute CD8-TL escape as early as 17 days postinfection, representing the earliest published example of CD8-TL escape in intrarectally infected macaques. These data demonstrate that pyrosequencing can be used to study the evolution of CD8-TL escape during immunodeficiency virus infection with an unprecedented degree of sensitivity.

机译：人和猿猴免疫缺陷病毒（HIV / SIV）在每个感染宿主内均表现出巨大的序列异质性。在这里，我们使用超深焦磷酸测序技术来绘制SIV感染猕猴中CD8 ^{+ T淋巴细胞（CD8-TL）逃逸的综合图，揭示了以前未发现的病毒变体的复杂模式。这种提高的灵敏度使得最早在感染后17天就可以检测到急性CD8-TL逃逸，这代表了直肠内感染猕猴中CD8-TL逃逸的最早公开实例。这些数据表明，焦磷酸测序可用于研究免疫缺陷病毒感染过程中CD8-TL逃逸的进化，并具有前所未有的敏感性。}

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期刊名称 Journal of Virology
作者
Benjamin N. Bimber; Benjamin J. Burwitz; Shelby OConnor; Ann Detmer; Emma Gostick; Simon M. Lank; David A. Price; Austin Hughes; David OConnor;
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作者单位

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年(卷),期 2009(83),16
年度 2009
页码 8247–8253
总页数 7
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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1. Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and CD8+ lymphocyte-depleted rhesus macaques. [J] . Annamalai L, Bhaskar V, Pauley DR, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第2期

机译：短期联合抗逆转录病毒疗法对猿猴免疫缺陷病毒感染和CD8 +淋巴细胞耗竭的猕猴的脑病毒负荷的影响。
2. Impact of Short-Term Combined Antiretroviral Therapy on Brain Virus Burden in Simian Immunodeficiency Virus-Infected and CD8+ Lymphocyte-Depleted Rhesus Macaques [J] . Lakshmanan Annamalai, Veena Bhaskar, Douglas R. Pauley, The American journal of pathology. . 2010,第2期

机译：短期联合抗逆转录病毒疗法对猿猴免疫缺陷病毒感染和CD8 +淋巴细胞减少的猕猴的脑病毒负担的影响
3. Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis. [J] . Bissel SJ, Wang G, Trichel AM, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2006,第5期

机译：猿猴/巨噬细胞感染在猿猴免疫缺陷病毒感染的CD8 + T细胞缺失的猕猴中发展为慢病毒性脑炎的纵向分析。
4. Mental Health Ubiquitous Monitoring: Detecting Context-Enriched Sociability Patterns Through Complex Event Processing [C] . Ivan Rodrigues de Moura, Francisco José da Silva e Silva, Luciano Reis Coutinho, IEEE International Symposium on Computer-Based Medical Systems . 2020

机译：心理健康无处不在的监视：通过复杂的事件处理检测上下文丰富的社交模式
5. Central nervous system immune activation and the neuropathogenesis of pediatric acquired immune deficiency syndrome in the simian immunodeficiency virus-infected rhesus macaque (Macaca mulatta). [D] . Bowenkamp, Kathryn Elizabeth. 2002

机译：猿猴免疫缺陷病毒感染的恒河猴（Macaca mulatta）的中枢神经系统免疫激活和小儿获得性免疫缺陷综合症的神经发病机制。
6. P20-16. Ultra-deep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in SIV-infected macaques [O] . BJ Burwitz, BN Bimber, S OConnor, 2009

机译：P20-16。超深度焦磷酸测序可检测SIV感染猕猴中CD8 + T淋巴细胞逃逸的复杂模式
7. Ultradeep Pyrosequencing Detects Complex Patterns of CD8+ T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques▿ † [O] . Bimber, Benjamin N., Burwitz, Benjamin J., O'Connor, Shelby, 2009

机译：超深焦磷酸测序检测在猿猴免疫缺陷病毒感染的猕猴中CD8 + T淋巴细胞逃逸的复杂模式

Ultradeep Pyrosequencing Detects Complex Patterns of CD8+ T-Lymphocyte Escape in Simian Immunodeficiency Virus-Infected Macaques

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