【2h】

Regulation of meiotic chromatin loop size by chromosomal position.

机译:减数分裂染色质环大小的染色体位置调节。

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摘要

At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths differ dramatically for interstitially and terminally located hamster telomeric sequences. Sequences, telomeric or otherwise, located at chromosome termini, closely associate with the meiotic proteinaceous core, forming shorter loops than identical interstitial sequences. Thus, we present evidence that different chromatin packaging mechanisms exist for interstitial versus terminal chromosomal regions, which act separately from those operating at the level of the DNA sequence. Chromosomal position plays the dominant role in chromatin packaging.
机译:在减数分裂前期,染色质在蛋白质核周围成环,这些环的大小在物种之间变化。在转基因小鼠中不同位点的序列相关插入物的形态比较表明,环的大小也随染色体的地理位置而变化。类似地,对于仓间和末端定位的仓鼠端粒序列,染色质环长度差异很大。位于染色体末端的端粒或其他序列与减数分裂蛋白核紧密相关,形成比相同间隙序列更短的环。因此,我们提供的证据表明,间质与末端染色体区域存在着不同的染色质包装机制,这些机制与在DNA序列水平上运作的染色体机制不同。染色体位置在染色质包装中起主要作用。

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