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Nonlinear control of heart rate variability in human infants.

机译:人类婴儿心率变异性的非线性控制。

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摘要

Nonlinear analyses of infant heart rhythms reveal a marked rise in the complexity of the electrocardiogram with maturation. We find that normal mature infants (gestation greater than or equal to 35 weeks) have complex and distinctly nonlinear heart rhythms (consistent with recent reports for healthy adults) but that such nonlinearity is lacking in preterm infants (gestation > or = to 27 weeks) where parasympathetic-sympathetic interaction and function are presumed to be less well developed. Our study further shows that infants with clinical brain death and those treated with atropine exhibit a similar lack of nonlinear feedback control. These three lines of evidence support the hypothesis championed by Goldberger et al. [Goldberger, A.L., Rigney, D.R. & West, B.J. (1990) Sci. Am. 262, 43-49] that autonomic nervous system control underlies the nonlinearity and possible chaos of normal heart rhythms. This report demonstrates the acquisition of nonlinear heart rate dynamics and possible chaos in developing human infants and its loss in brain death and with the administration of atropine. It parallels earlier work documenting changes in the variability of heart rhythms in each of these cases and suggests that nonlinearity may provide additional power in characterizing physiological states.
机译:婴儿心律的非线性分析显示,随着成熟,心电图的复杂性显着增加。我们发现正常的成熟婴儿(妊娠期大于或等于35周)具有复杂且明显的非线性心律(与健康成年人的最新报道一致),但是早产儿缺乏这种非线性(妊娠>或=至27周)假定副交感-交感的相互作用和功能发展较差。我们的研究进一步表明,患有临床脑死亡的婴儿和接受阿托品治疗的婴儿表现出相似的缺乏非线性反馈控制的现象。这三点证据支持Goldberger等人提出的假设。 [Goldberger,A.L.,Rigney,D.R. &B.J.&West,1990)。上午。 [262,43-49],自主神经系统控制是正常心律的非线性和可能混乱的基础。该报告证明了在发展中的人类婴儿中获得非线性心率动力学和可能出现的混乱,以及由于阿托品的管理而导致的大脑死亡损失。它与早期的工作相似,记录了在每种情况下心律变异性的变化,并表明非线性可能为表征生理状态提供额外的动力。

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