Supramolecular Chemistry And Self-assembly Special Feature: Transmembrane pores formed by syntheticp-octiphenyl β-barrels with internal carboxylateclusters: Regulation of ion transport by pH andMg2+- complexed 8-aminonaphthalene-136-trisulfonate

机译：超分子化学和自组装特征：合成膜形成的跨膜孔具有内部羧酸盐的对-辛苯基β-桶团簇：通过pH和pH调节离子迁移Mg2 +-络合的8-氨基萘-136-三磺酸盐

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Design, synthesis, and study of a synthetic barrel-stave supramolecule with p-octiphenyl “staves,” β-sheet “hoops,” and hydrophobic exterior as well as internal carboxylate clusters are reported. Ion transport experiments indicate the formation of transmembrane pores at 5 < pH < 7 with nanomolar activity. Blockage of dye efflux from spherical bilayers by external Mg(OAc)2 and internal 8-aminonaphthalene-1,3,6-trisulfonate is suggestive for weakly cooperative (n = 1.16) formation of aspartate-Mg²⁺-8-aminonaphthalene-1,3,6-trisulfonate complexes within the barrel-stave supramolecule (KD = 2.9 mM). Corroborative evidence from structural studies by circular dichroism spectroscopy is provided and discussed with emphasis of the importance of internal charge repulsion for pore formation and future applications toward binding and catalysis within supramolecular synthetic pores.

机译：据报道，合成，设计和合成了带有对-辛苯基“杆”，β-折叠“环”和疏水性外部以及内部羧酸盐簇的合成桶形超分子。离子传输实验表明在5 H <7的条件下具有纳摩尔活性的跨膜孔的形成。外部Mg（OAc）2和内部8-氨基萘-1,3,6-三磺酸盐阻止球形双层的染料流出，提示天冬氨酸-Mg ^{2 + -8-氨基萘-1,3,6-三磺酸盐络合物（KD = 2.9 mM）。提供并讨论了通过圆二色性光谱进行的结构研究的确证证据，重点讨论了内部电荷排斥对于孔形成的重要性以及未来在超分子合成孔内对结合和催化的应用的重要性。}

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期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Gopal Das; Stefan Matile;
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年(卷),期 2002(99),8
年度 2002
页码 5183–5188
总页数 6
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机译：跨膜孔由具有内部羧酸盐簇的合成对-邻苯基苯基桶形成。 pH和Mg2 +络合的8-氨基萘-1,3,6-三磺酸盐对离子迁移的调节

Supramolecular Chemistry And Self-assembly Special Feature: Transmembrane pores formed by syntheticp-octiphenyl β-barrels with internal carboxylateclusters: Regulation of ion transport by pH andMg2+- complexed 8-aminonaphthalene-136-trisulfonate

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