首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Carbon dioxide mediates Mn(II)-catalyzed decomposition of hydrogen peroxide and peroxidation reactions
【2h】

Carbon dioxide mediates Mn(II)-catalyzed decomposition of hydrogen peroxide and peroxidation reactions

机译:二氧化碳介导Mn(II)催化的过氧化氢分解和过氧化反应

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Mn(II) can catalyze the decomposition of H2O2 and, in the presence of H2O2, can catalyze the oxidation of NADH. Strikingly, these processes depend on the simultaneous presence of both CO2 and . This explains the exponential dependence of the rates on [], previously noted by other workers. These processes are inhibited by Mn-superoxide dismutase, establishing the generation of and its role as an essential reactant. A scheme of reactions, consistent with the known properties of this system, is proposed. The large rate enhancements provided by + CO2, and the abundance of both of these species in vivo, suggest that similar reactions have relevance to the oxidative stress imposed by and H2O2.
机译:Mn(II)可以催化H2O2的分解,并且在H2O2存在下可以催化NADH的氧化。令人惊讶的是,这些过程取决于同时存在CO2和。这就解释了费率对[]的指数依赖性,以前其他工人已经注意到。锰超氧化物歧化酶可抑制这些过程,从而确定Mn的生成及其作为基本反应物的作用。提出了与该系统的已知性质一致的反应方案。 + CO2提供的大量速率增强以及体内这两种物质的丰度表明相似的反应与H2O2施加的氧化应激有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号