• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >Apelin a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release
【2h】

Apelin a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release

机译：Apelin一种有效的利尿神经肽可通过抑制加压素神经元活性和加压素释放来抵消加压素的作用

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apelin, a recently isolated neuropeptide that is expressed in the supraoptic and the paraventricular nuclei, acts on specific receptors located on vasopressinergic neurons. The increased phasic pattern of these neurons facilitates sustained antidiuresis during dehydration or lactation. Here, we investigated whether apelin interacts with arginine vasopressin (AVP) to maintain body fluid homeostasis. We first characterized the predominant molecular forms of endogenous hypothalamic and plasma apelin as corresponding to apelin 13 and, to a lesser extent, to apelin 17. We then demonstrated that, in lactating rats, apelin was colocalized with AVP in supraoptic nucleus magnocellular neurons and given intracerebroventricularly inhibited the phasic electrical activity of AVP neurons. In lactating mice, intracerebroventricular administration of apelin 17 reduced plasma AVP levels and increased diuresis. Moreover, water deprivation, which increases systemic AVP release and causes depletion of hypothalamic AVP stores, decreased plasma apelin concentrations and induced hypothalamic accumulation of the peptide, indicating that AVP and apelin are conversely regulated to facilitate systemic AVP release and suppress diuresis. Opposite effects of AVP and apelin are likely to occur at the hypothalamic level through autocrine modulation of the phasic electrical activity of AVP neurons. Altogether, these data demonstrate that apelin acts as a potent diuretic neuropeptide counteracting AVP actions through inhibition of AVP neuron activity and AVP release. The coexistence of apelin and AVP in magnocellular neurons, their opposite biological effects, and regulation are likely to play a key role for maintaining body fluid homeostasis.
机译：Apelin是一种最近分离的神经肽，在视上和脑室旁核中表达，作用于血管加压素神经元上的特定受体。这些神经元的增加的相位模式促进了脱水或泌乳期间持续的抗利尿作用。在这里，我们调查了apelin是否与精氨酸加压素（AVP）相互作用以维持体液稳态。我们首先将内源性下丘脑和血浆apelin的主要分子形式表征为apelin 13，并在较小程度上相当于apelin17。然后我们证明，在哺乳期大鼠中，apelin与AVP在视光上核巨细胞神经元中共定位并给予脑室内抑制AVP神经元的相位电活动。在哺乳期小鼠中，脑室内给予apelin 17会降低血浆AVP水平并增加利尿作用。此外，缺水会增加系统性AVP的释放并导致下丘脑AVP储存的耗尽，降低血浆apelin的浓度并诱导下丘脑的肽积聚，这表明AVP和apelin的调节反过来有利于系统性AVP的释放和利尿。通过自分泌调节AVP神经元的相电活动，在下丘脑水平可能发生AVP和apelin的相反作用。总而言之，这些数据表明，apelin通过抑制AVP神经元活性和AVP释放，作为有效的利尿神经肽来抵消AVP的作用。 apelin和AVP在大细胞神经元中的共存，它们相反的生物学作用以及调节作用可能对维持体液稳态起关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号