Conserved T cell receptor α-chain induces insulin autoantibodies

机译：保守的T细胞受体α链诱导胰岛素自身抗体

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

A fundamental question is what are the molecular determinants that lead to spontaneous preferential targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9–23 peptide sequence in type 1 diabetes. Anti-insulin B:9–23 T cell clones isolated from prediabetic NOD islets have a conserved Vα-segment/Jα-segment, but no conservation of the α-chain N region and no conservation of the Vβ-chain. Here, we show that the conserved T cell receptor α-chain generates insulin autoantibodies when transgenically or retrogenically introduced into mice without its corresponding Vβ. We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved α chain T cell receptor.

机译：一个基本的问题是，在自身免疫性疾病（例如1型糖尿病中的胰岛素B：9-23肽序列）中，哪些分子决定因素会导致自发性优先靶向特定的自身抗原。从糖尿病前期NOD胰岛分离的抗胰岛素B：9-23 T细胞克隆具有保守的Vα段/Jα段，但无α链N区保守性和Vβ链保守性。在这里，我们显示了保守的T细胞受体α链在没有相应Vβ的情况下通过转基因或逆转录导入小鼠体内时会产生胰岛素自身抗体。我们建议，关于胰岛自身免疫性为什么会发展的谜团的一个主要部分是关于保守α链T细胞受体对一级胰岛素肽的识别。

著录项

期刊名称 Proceedings of the National Academy of Sciences of the United States of America
作者
Masakazu Kobayashi; Jean Jasinski; Edwin Liu; Marcella Li; Dongmei Miao; Li Zhang; Liping Yu; Maki Nakayama; George S. Eisenbarth;
展开▼
作者单位

展开▼
年(卷),期 2008(105),29
年度 2008
页码 10090–10094
总页数 5
原文格式 PDF
正文语种
中图分类
关键词
autoimmunity NOD mouse Type 1 diabetes retrogenic;

机译：自身免疫;NOD小鼠;1型糖尿病;逆转;

相似文献

外文文献
中文文献
专利

1. Conserved T cell receptor a-chain induces insulin autoantibodies [J] . Masakazu Kobayashi, Jean Jasinski, Edwin Liu, Proceedings of the National Academy of Sciences of the United States of America . 2008,第29期

机译：保守的T细胞受体α链诱导胰岛素自身抗体
2. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. [J] . Zhang L, Jasinski JM, Kobayashi M Journal of Autoimmunity . 2009,第1期

机译：分析与显性保守TRAV5D-4 * 04抗胰岛素B：9-23α链结合的T细胞受体β链。
3. Recurrent hypoglycemia during pregnancies in a woman with multiple autoantibodies including anti-insulin receptor antibody and anti-pl atelet antibody, whose serum lowered murine blood glucose levels and phosphorylated insulin receptor of CHO-IR cells [J] . Makiko Toshihiro, Hideki Katagiri, Koujiro Kataoka, Endocrine journal . 2011,第12期

机译：患有多种自身抗体（包括抗胰岛素受体抗体和抗血小板抗体）的妇女在怀孕期间反复出现低血糖，其血清降低了鼠血糖水平和CHO-IR细胞的磷酸化胰岛素受体
4. Nano Flow LC-MS Analyses of Insulin Receptor Site-specific Phosphorylation Induced by Insulin Lispro and Basal Insulin Peglispro [C] . Zhongping Liao, Mark W. Farmen, Jason X. Tang, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：纳米流动LC-MS分析胰岛素LISPRO诱导的胰岛素受体特异性磷酸化磷酸化，基础胰岛素PEGLISPRO
5. T cell development and gamma/delta T cell antigen receptor: I. Structure and rearrangement of murine T cell antigen receptor delta chain gene. II. Expression of fetal type gamma/delta T cell receptor in adult transgenic mice and its effects on T cell development. [D] . Iwashima, Makio. 1990

机译：T细胞发育和γ/δT细胞抗原受体：I.鼠T细胞抗原受体δ链基因的结构和重排。二。胎儿型γ/δT细胞受体在成年转基因小鼠中的表达及其对T细胞发育的影响。
6. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains [O] . Li Zhang, Jean M. Jasinski, Masakazu Kobayashi, -1

机译：与占优势保守的Trav5D-4 * 04抗胰岛素B：9-23α链相结合的T细胞受体β链分析
7. Conserved T cell receptor α-chain induces insulin autoantibodies [O] . Kobayashi, Masakazu, Jasinski, Jean, Liu, Edwin, 2008

机译：保守的T细胞受体α链诱导胰岛素自身抗体

Conserved T cell receptor α-chain induces insulin autoantibodies

摘要

著录项

相似文献

相关主题

期刊订阅