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Complete Genome Sequence Analysis of a Recent Chicken Anemia Virus Isolate and Comparison with a Chicken Anemia Virus Isolate from Human Fecal Samples in China

机译:近期鸡贫血病毒分离株的完整基因组序列分析和与中国人粪便样品中鸡贫血病毒分离株的比较

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摘要

A new isolate of chicken anemia virus (CAV) was designated GD-1-12. GD-1-12 was isolated from a 12-day-old commercial broiler in Guangdong province, China, in 2012. The GD-1-12 CAV caused high mortality, severe anemia, thymic atrophy, and subcutaneous hemorrhage in commercial broilers. Here, we report the complete genome sequence of GD-1-12 CAV and comparison with the complete genome sequence of another CAV that was isolated from human fecal samples in China (GenBank accession no. ). The genomes of the two CAV isolates shared high homology, although a deletion was identified by comparison. The findings from this study provide additional insights into the molecular characteristics of the CAV genomes and should advance knowledge for continuous monitoring and, perhaps, preventing the spread of the virus in chickens as well as in humans.
机译:一种新的鸡贫血病毒(CAV)分离株命名为GD-1-12。 GD-1-12于2012年从中国广东省一家12天大的商业肉鸡中分离出来。GD-1-12CAV导致商业肉鸡的高死亡率,严重贫血,胸腺萎缩和皮下出血。在这里,我们报告了GD-1-12 CAV的完整基因组序列,并与从中国人粪便样品中分离的另一CAV的完整基因组序列进行了比较(GenBank登录号)。两个CAV分离株的基因组具有高度同源性,尽管通过比较确定了缺失。这项研究的发现为CAV基因组的分子特征提供了更多的见解,并应为连续监测和预防病毒在鸡以及人类中的传播提供知识。

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