• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >From the Cover: Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia
【2h】

From the Cover: Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia

机译：从封面：八环素1（TMEM16A）对于睾丸激素诱导的前列腺增生至关重要

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate, causing lower urinary tract symptoms in elderly men worldwide. However, the molecular mechanism underlying the pathogenesis of BPH is unclear. Anoctamin1 (ANO1) encodes a Ca2+-activated chloride channel (CaCC) that mediates various physiological functions. Here, we demonstrate that it is essential for testosterone-induced BPH. ANO1 was highly amplified in dihydrotestosterone (DHT)-treated prostate epithelial cells, whereas the selective knockdown of ANO1 inhibited DHT-induced cell proliferation. Three androgen-response elements were found in the ANO1 promoter region, which is relevant for the DHT-dependent induction of ANO1. Administration of the ANO1 blocker or Ano1 small interfering RNA, inhibited prostate enlargement and reduced histological abnormalities in vivo. We therefore concluded that ANO1 is essential for the development of prostate hyperplasia and is a potential target for the treatment of BPH.
机译：良性前列腺增生（BPH）的特征是前列腺增大，在全世界的老年男性中引起下尿路症状。但是，尚不清楚BPH发病机理的分子机制。 Anoctamin1（ANO1）编码一个Ca 2 + 激活的氯离子通道（CaCC），该通道介导各种生理功能。在这里，我们证明它对于睾丸激素诱导的BPH至关重要。 ANO1在二氢睾丸激素（DHT）处理过的前列腺上皮细胞中高度扩增，而选择性敲低ANO1抑制DHT诱导的细胞增殖。在ANO1启动子区域发现了三个雄激素响应元件，这与DHT依赖的ANO1诱导有关。给予ANO1受体阻滞剂或Ano1小干扰RNA，可抑制体内前列腺肥大并减少组织异常。因此，我们得出结论，ANO1对前列腺增生的发展至关重要，并且是治疗BPH的潜在靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号