• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Proceedings of the National Academy of Sciences of the United States of America >PNAS Plus: Tectal microcircuit generating visual selection commands on gaze-controlling neurons
【2h】

PNAS Plus: Tectal microcircuit generating visual selection commands on gaze-controlling neurons

机译：PNAS Plus：直肠微电路在注视控制神经元上生成视觉选择命令

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The optic tectum (called superior colliculus in mammals) is critical for eye–head gaze shifts as we navigate in the terrain and need to adapt our movements to the visual scene. The neuronal mechanisms underlying the tectal contribution to stimulus selection and gaze reorientation remains, however, unclear at the microcircuit level. To analyze this complex—yet phylogenetically conserved—sensorimotor system, we developed a novel in vitro preparation in the lamprey that maintains the eye and midbrain intact and allows for whole-cell recordings from prelabeled tectal gaze-controlling cells in the deep layer, while visual stimuli are delivered. We found that receptive field activation of these cells provide monosynaptic retinal excitation followed by local GABAergic inhibition (feedforward). The entire remaining retina, on the other hand, elicits only inhibition (surround inhibition). If two stimuli are delivered simultaneously, one inside and one outside the receptive field, the former excitatory response is suppressed. When local inhibition is pharmacologically blocked, the suppression induced by competing stimuli is canceled. We suggest that this rivalry between visual areas across the tectal map is triggered through long-range inhibitory tectal connections. Selection commands conveyed via gaze-controlling neurons in the optic tectum are, thus, formed through synaptic integration of local retinotopic excitation and global tectal inhibition. We anticipate that this mechanism not only exists in lamprey but is also conserved throughout vertebrate evolution.
机译：当我们在地形中导航并且需要使我们的动作适应视觉场景时，视神经台（在哺乳动物中称为上丘）对于眼目凝视转移至关重要。顶盖对刺激选择和凝视重新定向的贡献的神经机制仍然存在，但是在微电路水平尚不清楚。为了分析这种复杂的系统发育保守的感觉运动系统，我们在七rey鳗中开发了一种新型的体外制剂，该制剂可保持眼睛和中脑完整，并允许从预先标记的眼睑注视控制细胞在深层进行全细胞记录，而视觉刺激被传递。我们发现这些细胞的受体场激活提供了单突触的视网膜兴奋，然后是局部的GABA能抑制（前馈）。另一方面，整个剩余的视网膜仅引起抑制（周围抑制）。如果同时传递两种​​刺激，一种在接受野的内部，另一种在接受野的外部，那么前者的兴奋反应就会被抑制。当局部抑制在药理学上被阻断时，由竞争性刺激引起的抑制被取消。我们建议，通过远距离抑制性顶盖连接可以触发整个顶盖地图视觉区域之间的竞争。因此，通过视神经保护层中视线控制神经元传达的选择命令是通过局部视网膜激活和总的抑制作用的突触整合形成的。我们预期该机制不仅存在于七lamp鳗中，而且在整个脊椎动物进化过程中也被保守。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号