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Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes

机译：大规模分析人类乳头瘤病毒16型E6和E7致癌基因永生化的人角质形成细胞中蛋白质表达的变化

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BackgroundInfection with high-risk type human papilloma viruses (HPVs) is associated with cervical carcinomas and with a subset of head and neck squamous cell carcinomas. Viral E6 and E7 oncogenes cooperate to achieve cell immortalization by a mechanism that is not yet fully understood. Here, human keratinocytes were immortalized by long-term expression of HPV type 16 E6 or E7 oncoproteins, or both. Proteomic profiling was used to compare expression levels for 741 discrete protein features.

机译：背景高危型人乳头瘤病毒（HPV）感染与子宫颈癌和一部分头颈部鳞状细胞癌有关。病毒E6和E7癌基因通过尚未完全了解的机制协同作用，实现了细胞永生化。在这里，人类角质形成细胞通过HPV 16型E6或E7癌蛋白或两者的长期表达而永生。蛋白质组分析用于比较741个离散蛋白质特征的表达水平。

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期刊名称 Proteome Science
作者
Mark A Merkley; Ellen Hildebrandt; Robert H Podolsky; Hilal Arnouk; Daron G Ferris; William S Dynan; Hubert Stöppler;
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年(卷),期 2009(7),-1
年度 2009
页码 29
总页数 15
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
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专利

1. Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes [J] . Mark A Merkley, Ellen Hildebrandt, Robert H Podolsky, Proteome science . 2009,第1期

机译：大规模分析人乳头瘤病毒16型E6和E7致癌基因永生化的人角质形成细胞中蛋白质表达的变化
2. Expression and localization of human papillomavirus type 16 E6 and E7 open reading frame proteins in human epidermal keratinocyte [J] . Kim Kun Hong, Yoon Do Jun, Moon Young Ah, Yonsei Medical Journal . 1994,第1期

机译：人乳头瘤病毒16型E6和E7开放阅读框蛋白在人表皮角质形成细胞中的表达和定位
3. Prime-boost therapeutic vaccination in mice with DNA/DNA or DNA/Fowlpox virus recombinants expressing the Human Papilloma Virus type 16 E6 and E7 mutated proteins fused to the coat protein of Potato virus X [J] . Illiano Elena, Bissa Massimiliano, Paolini Francesca, Virus Research: An International Journal of Molecular and Cellular Virology . 2016,第Null期

机译：用表达与马铃薯X病毒外壳蛋白融合的16型人乳头瘤病毒E6和E7突变蛋白的DNA / DNA或DNA /禽流感病毒重组子在小鼠中进行初免免疫治疗性疫苗接种
4. Identification and expression of human papilloma virus type 16 L1 Gene in E.coli [C] . Daohong Lin, Zhuangmin, Linghong, 7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai . 2000

机译：人乳头瘤病毒16型L1基因在大肠杆菌中的鉴定和表达
5. Human papillomavirus type 16 E6 and E7 oncogene expression in relation to host cell growth and differentiation. [D] . Choo, Chee Keong. 1994

机译：人乳头瘤病毒16型E6和E7癌基因表达与宿主细胞生长和分化有关。
6. Insulin-Like Growth Factor-Binding Protein 3 Expression Increases during Immortalization of Cervical Keratinocytes by Human Papillomavirus Type 16 E6 and E7 Proteins [O] . Allison J. Berger, Astrid Baege, Tracy Guillemette, 2002

机译：胰岛素样生长因子结合蛋白3在人乳头瘤病毒16型E6和E7蛋白使宫颈角质形成细胞永生化过程中表达增加。
7. Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes [O] . Mark A Merkley, Ellen Hildebrandt, Robert H Podolsky, 2009

机译：大规模分析人类乳头瘤病毒16型E6和E7致癌基因永生化的人角质形成细胞中蛋白质表达的变化
8. Decreased Migration of Langerhans Precursor-Like Cells in Response to Human Keratinocytes Expressing HPV-16 E6/E7 is Related to Reduced Macrophage Inflammatory Protein-3Alpha Production [R] . Guess, J. C. , McCance, D. J. 2005

机译：降低朗格汉斯前体样细胞的迁移响应人类角质形成细胞表达HpV-16 E6 / E7与减少的巨噬细胞炎症蛋白-3α生成相关

Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes

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