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Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

机译：基于具有氢键能力的分子的功能材料：在药物共晶体和聚合物复合物中的应用

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The design, synthesis and property characterization of new functional materials has garnered interest in a variety of fields. Materials that are capable of recognizing and binding with small molecules have applications in sensing, sequestration, delivery and property modification. Specifically, recognition of pharmaceutical compounds is of interest in each of the aforementioned application areas. Numerous pharmaceutical compounds comprise functional groups that are capable of engaging in hydrogen-bonding interactions; thus, materials that are able to act as hydrogen-bond receptors are of significant interest for these applications. In this review, we highlight some crystalline and polymeric materials that recognize and engage in hydrogen-bonding interactions with pharmaceuticals or small biomolecules. Moreover, as pharmaceuticals often exhibit multiple hydrogen-bonding sites, many donor/acceptor molecules have been specifically designed to interact with the drug via such multiple-point hydrogen bonds. The formation of multiple hydrogen bonds not only increases the strength of the interaction but also affords unique hydrogen-bonded architectures.

机译：新功能材料的设计，合成和性能表征已在各个领域引起了人们的兴趣。能够识别小分子并与小分子结合的材料可用于传感，螯合，传递和特性修饰。具体而言，在上述每个应用领域中，人们都对药物化合物的识别感兴趣。许多药物化合物包含能够参与氢键相互作用的官能团；因此，对于这些应用而言，能够充当氢键受体的材料引起了人们的极大兴趣。在这篇综述中，我们重点介绍了一些晶体和聚合材料，它们可以识别并参与与药物或小生物分子的氢键相互作用。此外，由于药物通常表现出多个氢键位，因此许多供体/受体分子已被专门设计成通过这种多点氢键与药物相互作用。多个氢键的形成不仅增加了相互作用的强度，而且提供了独特的氢键结构。

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期刊名称 Royal Society Open Science
作者
Kristin M. Hutchins;
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作者单位

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年(卷),期 2018(5),6
年度 2018
页码 180564
总页数 16
原文格式 PDF
正文语种
中图分类
关键词
hydrogen bonding pharmaceuticals co-crystal polymer;

机译：氢键;药物;共晶;聚合物;

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机译：β-环糊精聚合物与二乙烯基砜交联的内含物结合贡献的作用-对Morales-Sanfrutos等人的评论。题为“二乙烯基砜交联的环糊精基聚合物材料：作为吸收剂和包封剂的合成与应用”，分子，2015年，第20期，第3565-3581页。
2. The Role of Inclusion Binding Contributions for β-Cyclodextrin Polymers Cross-Linked with Divinyl Sulfone?—A Comment on Morales-Sanfrutos et al. Entitled “Divinyl Sulfone Cross-Linked Cyclodextrin-Based Polymeric Materials: Synthesis and Applications as Sorbents and Encapsulating Agents”, Molecules, 2015, 20, 3565–3581. [J] . Lee Wilson, Mohamed Mohamed, Dena McMartin Molecules . 2016,第1期

机译：β-环糊精聚合物与二乙烯基砜交联的包裹体结合贡献的作用？-对Morales-Sanfrutos等的评论。题为“二乙烯基砜交联的基于环糊精的聚合物材料：作为吸收剂和包封剂的合成与应用”，分子，2015年，第20期，第3565–3581页。
3. Metal complexes with polymeric ligands: Modular synthesis of multifunctional materials for applications in biomedicine and nanotechnology [J] . Bender JL., Johnson RM., Smith AP., Macromolecular symposia . 2002,第0期

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4. Functionalized aerogels and aerogel inspired materials for different applications: photoactive molecules stabilization and accelerated release of drugs [C] . N. Murillo-Cremaes, A. M. Lopez, J. Saurina, European Meeting on Supercritical Fluids . 2012

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5. New materials for optical sensing of explosives copolymers containing 2-vinyl-4,6-diamino-1,3,5-triazine and co-crystals of electron rich aromatic molecules and 1,3-dinitrobenzene. [D] . McNeil, Steven Keith. 2013

机译：用于爆炸物共聚物的光学传感的新材料，其中包含2-乙烯基-4,6-二氨基-1,3,5-三嗪以及富电子芳族分子和1,3-二硝基苯的共晶体。
6. The Role of Inclusion Binding Contributions for β-Cyclodextrin Polymers Cross-Linked with Divinyl Sulfone?—A Comment on Morales-Sanfrutos et al. Entitled Divinyl Sulfone Cross-Linked Cyclodextrin-Based Polymeric Materials: Synthesis and Applications as Sorbents and Encapsulating Agents Molecules 2015 20 3565–3581. [O] . Lee D. Wilson, Mohamed H. Mohamed, Dena W. McMartin 2016

机译：β-环糊精聚合物与二乙烯基砜交联的包裹体结合贡献的作用？-对Morales-Sanfrutos等人的评论。题为二乙烯基砜交联的基于环糊精的聚合物材料：作为吸收剂和包封剂的合成与应用分子2015年第20期第3565–3581页。
7. The Role of Inclusion Binding Contributions for β-Cyclodextrin Polymers Cross-Linked with Divinyl Sulfone?—A Comment on Morales-Sanfrutos et al. Entitled “Divinyl Sulfone Cross-Linked Cyclodextrin-Based Polymeric Materials: Synthesis and Applications as Sorbents and Encapsulating Agents”, Molecules, 2015, 20, 3565–3581. [O] . Lee D. Wilson, Mohamed H. Mohamed, Dena W. McMartin 2016

机译：β-Cyclodextrin聚合物与二乙烯基砜交叉连接的包含结合贡献的作用？-a morales-sanfrutos等人的评论。题为“二乙烯基砜交联环糊精的聚合物材料：作为吸附剂和包封剂的合成和应用”，molecules，2015,20,3565-3581。

Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

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