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首页> 美国卫生研究院文献>Reproductive Biology and Endocrinology : RBE >In-vitro effects of the antimicrobial peptide Ala81318-magainin II amide on isolated human first trimester villous trophoblast cells
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In-vitro effects of the antimicrobial peptide Ala81318-magainin II amide on isolated human first trimester villous trophoblast cells

机译：抗菌肽Ala81318-magainin II酰胺对分离的人早孕绒毛滋养层细胞的体外作用

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BackgroundResearch on antimicrobial cationic peptides (AMPs) has gained pace toward using their potential to replace conventional antibiotics. These peptides preferentially interact with negatively charged membrane lipids typically seen in bacteria and thereby lead to membrane perturbations and membrane dysfunction. However, one possible disadvantage of AMP drugs is their potential for toxicity, especially to those cells which display externalization of negatively charged moieties to the outer leaflet of the plasma membrane during the process of syncytialization. Human placental villous trophoblast is one such cell type. Indeed, intra-vaginal administration of an antimicrobial cationic peptide Ala8,13,18-magainin II amide (AMA) which is a synthetic analogue of magainin 2 derived from Xenopus frog has been observed to result in inhibition of pregnancy establishment in monkeys. However, only little is known about the cellular behavior of early placental cytotrophoblasts (CTB) in the presence of cationic antimicrobial peptides. It is believed that suitable cell culture approaches using AMA as a representative alpha-helical AMP may yield tangible knowledge in this regard.
机译：背景技术关于抗微生物阳离子肽（AMPs）的研究已朝着利用其替代常规抗生素的潜力迈进了一步。这些肽优先与细菌中常见的带负电荷的膜脂质相互作用，从而导致膜扰动和膜功能障碍。然而，AMP药物的一个可能的缺点是其潜在的毒性，特别是对那些在合胞化过程中向细胞膜外小叶显示带负电部分的外部化的细胞。人胎盘绒毛滋养层细胞就是这样一种细胞类型。实际上，已观察到阴道内施用抗菌阳离子肽Ala8,13,18-magainin II酰胺（AMA），它是非洲爪蟾蛙的magainin 2的合成类似物，可抑制猴子的怀孕。但是，关于早期的胎盘滋养细胞（CTB）在阳离子抗菌肽存在下的细胞行为了解甚少。相信使用AMA作为代表性的α-螺旋AMP的合适的细胞培养方法可以在这方面产生切实的知识。

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