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Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics

机译：卵泡液含量和卵母细胞质量：从单一生化标志物到代谢组学

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摘要

The assessment of oocyte quality in human in vitro fertilization (IVF) is getting increasing attention from embryologists. Oocyte selection and the identification of the best oocytes, in fact, would help to limit embryo overproduction and to improve the results of oocyte cryostorage programs. Follicular fluid (FF) is easily available during oocyte pick-up and theorically represents an optimal source on non-invasive biochemical predictors of oocyte quality. Unfortunately, however, the studies aiming to find a good molecular predictor of oocyte quality in FF were not able to identify substances that could be used as reliable markers of oocyte competence to fertilization, embryo development and pregnancy. In the last years, a well definite trend toward passing from the research of single molecular markers to more complex techniques that study all metabolites of FF has been observed. The metabolomic approach is a powerful tool to study biochemical predictors of oocyte quality in FF, but its application in this area is still at the beginning. This review provides an overview of the current knowledge about the biochemical predictors of oocyte quality in FF, describing both the results coming from studies on single biochemical markers and those deriving from the most recent studies of metabolomics
机译：胚胎学家对人类体外受精（IVF）中卵母细胞质量的评估越来越受到关注。实际上，卵母细胞的选择和最佳卵母细胞的鉴定将有助于限制胚胎的过度生产并改善卵母细胞冷冻保存程序的结果。卵母细胞摄取过程中很容易获得卵泡液（FF），从理论上讲，它是卵母细胞质量无创生化指标的最佳来源。然而不幸的是，旨在寻找FF中卵母细胞质量的良好分子预测因子的研究未能鉴定出可作为卵母细胞受精，胚胎发育和妊娠能力的可靠标志物的物质。在过去的几年中，已经观察到一个明确的趋势，即从单一分子标记物的研究转向研究FF所有代谢物的更复杂技术的趋势。代谢组学方法是研究FF卵母细胞质量的生化预测因子的有力工具，但在这一领域的应用仍处于起步阶段。这篇综述概述了关于FF中卵母细胞质量的生化预测因子的当前知识，描述了来自单一生化标记物研究的结果以及来自最新代谢组学研究的结果

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