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Diagnosis and treatment of immunologically infertile males with antisperm antibodies

机译:抗精子抗体对免疫性不育男性的诊断和治疗

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摘要

The presence of antisperm antibodies (ASA) can reduce fecundity in both males and females. The present review describes a strategy, established by investigations of the diverse inhibitory effects of ASA on fertility, for the appropriate diagnosis and treatment of infertile males with ASA. For infertile males with ASA, diagnosis using the direct‐immunobead test (D‐IBT), the postcoital test (PCT) and the hemizona assay (HZA) should be carried out as the basis for decision‐making. If the patient with ASA has an abnormal hemizona index, it seems reasonable to advise selecting intracytoplasmic sperm injection‐embryo transfer (ICSI‐ET) as a primary treatment. However, it has been shown that some immunologically infertile males with normal fertilizing ability established pregnancy by timed intercourse (TI) or intrauterine insemination (IUI). In such patients with ASA having normal hemizona index, TI or IUI can be selected based on the PCT result. Therefore, the treatment strategy for males with ASA is similar to that for infertile males with oligozoospermia or asthenozoospermia.In conclusion, it should be emphasized that a diversity of ASA exists and their effects on fertility in infertile males. Although there is an argument that routine testing for ASA in males is not always necessary, one should be aware that in some cases of failed IUI or IVF, ICSI is selected afterward because of the diagnosis of ASA. (Reprod Med Biol 2005; >4: 133–141)
机译:抗精子抗体(ASA)的存在可降低雄性和雌性的繁殖力。本综述描述了一种通过对ASA对生育力的多种抑制作用进行研究而确立的策略,用于适当诊断和治疗ASA的不育男性。对于患有ASA的不育男性,应使用直接免疫血脂试验(D-IBT),性交后试验(PCT)和半渗血试验(HZA)进行诊断,以此作为决策的基础。如果ASA患者的半透明指数异常,建议选择胞浆内精子注射-胚胎移植(ICSI-ET)作为主要治疗方法似乎是合理的。但是,已经证明,一些具有正常受精能力的免疫不育男性通过定时性交(TI)或宫内授精(IUI)建立了妊娠。在具有半衰期指数正常的ASA患者中,可以根据PCT结果选择TI或IUI。因此,男性ASA的治疗策略与少精症或弱精子症的不育男性的治疗策略相似。总而言之,应该强调的是,ASA的多样性及其对不育男性生育能力的影响。尽管有一种观点认为不总是需要对男性进行ASA常规检测,但应注意,在某些IUI或IVF失败的情况下,由于诊断为ASA,因此之后才选择ICSI。 (Reprod Med Biol 2005; > 4 :133–141)

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