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Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

机译：建立对HIV高度敏感并适用于高通量评估CCR5和CXCR4拮抗剂的新型表达CCR5和CXCR4的CD4 +细胞系

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摘要

BackgroundCCR5 and CXCR4 are the two main coreceptors essential for HIV entry. Therefore, these chemokine receptors have become important targets in the search for anti-HIV agents. Here, we describe the establishment of a novel CD4⁺cell line, U87.CD4.CCR5.CXCR4, stably expressing both CCR5 and CXCR4 at the cell surface.

机译：背景技术CCR5和CXCR4是HIV进入必不可少的两个主要受体。因此，这些趋化因子受体已成为寻找抗HIV药物的重要靶标。在这里，我们描述了新型CD4 ^{+ 细胞系U87.CD4.CCR5.CXCR4的建立，该细胞系在细胞表面稳定表达CCR5和CXCR4。}

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期刊名称 Retrovirology
作者
Katrien Princen; Sigrid Hatse; Kurt Vermeire; Erik De Clercq; Dominique Schols;
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年(卷),期 2004(1),-1
年度 2004
页码 2
总页数 13
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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1. Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists [J] . Katrien Princen, Sigrid Hatse, Kurt Vermeire, Retrovirology . 2004,第2009期

机译：表达对HIV高度敏感并适合高通量评估CCR5和CXCR4拮抗剂的新型表达CD4 + 的CCR5和CXCR4细胞系的建立
2. Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patients. [J] . Wolday D, Tegbaru B, Kassu A, JAIDS: Journal of acquired immune deficiency syndromes . 2005,第3期

机译：HIV-1合并感染的患者在活动性肺结核治疗期间CD4 + T细胞上趋化因子受体CCR5和CXCR4的表达以及血浆趋化因子水平。
3. CCR5 and CXCR4 expression on memory and naive T cells in HIV-1 infection and response to highly active antiretroviral therapy. [J] . Nicholson JK, Browning SW, Hengel RL, JAIDS: Journal of acquired immune deficiency syndromes . 2001,第2期

机译：CCR5和CXCR4在HIV-1感染的记忆和幼稚T细胞中的表达以及对高效抗逆转录病毒疗法的反应。
4. Predicting the Co-receptors (CCR5 and CXCR4) of the Viruses R5, X4 and R5X4 that Cause AIDS (HIV-1) in Cells CD4 using The Bayes Classifier [C] . Francisco Javier Luna Rosas, Julio Cesar Martinez Romo, Carlos Alejandro de Luna Ortega, International Conference on Bioinformatics and Computational Biology . 2014

机译：预测病毒R5，X4和R5X4的共同受体（CCR5和CXCR4），其使用贝叶斯分类器导致细胞CD4中的艾滋病（HIV-1）
5. Studies of Protein Interactions and Knowledge-Based Drug Design: (A) The Electrostatic Nature of Recognition Between HIV-1 gp120 V3 Loop and Coreceptors CCR5/CXCR4, (B) Complement System Inhibition by Compstatin Family Peptides [D] . Lopez de Victoria Suarez, Aliana 2012

机译：蛋白质相互作用和基于知识的药物设计的研究：（A）HIV-1 gp120 V3环与共受体CCR5 / CXCR4之间识别的静电性质，（B）坎普他汀家族肽对补体系统的抑制作用
6. The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro [O] . Shay Matalon, Brent E. Palmer, Marcel F. Nold, -1

机译：组蛋白脱乙酰化酶抑制剂ITF2357降低CD4 + T细胞和单核细胞的表面CXCR4和CCR5表达并优于丙戊酸用于体外潜伏的HIV-1表达
7. Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists [O] . Princen Katrien, Hatse Sigrid, Vermeire Kurt, 2004

机译：建立对HIV高度敏感并适用于高通量评估CCR5和CXCR4拮抗剂的新型表达CCR5和CXCR4的CD4 +细胞系

Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

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