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Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain

机译：EIAV gp45疫苗株中发现的V / I505T突变的结构和生化见解

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BackgroundThe equine infectious anemia virus (EIAV) is a lentivirus of the Retrovirus family, which causes persistent infection in horses often characterized by recurrent episodes of high fever. It has a similar morphology and life cycle to the human immunodeficiency virus (HIV). Its transmembrane glycoprotein, gp45 (analogous to gp41 in HIV), mediates membrane fusion during the infection. However, the post-fusion conformation of EIAV gp45 has not yet been determined. EIAV is the first member of the lentiviruses for which an effective vaccine has been successfully developed. The attenuated vaccine strain, FDDV, has been produced from a pathogenic strain by a series of passages in donkey dermal cells. We have previously reported that a V/I505T mutation in gp45, in combination with other mutations in gp90, may potentially contribute to the success of the vaccine strain. To this end, we now report on our structural and biochemical studies of the gp45 protein from both wide type and vaccine strain, providing a valuable structural model for the advancement of the EIAV vaccine.
机译：背景马传染性贫血病毒（EIAV）是逆转录病毒家族的一种慢病毒，可引起马的持续感染，其特征通常是高烧反复发作。它具有与人类免疫缺陷病毒（HIV）类似的形态和生命周期。其跨膜糖蛋白gp45（类似于HIV中的gp41）在感染过程中介导膜融合。但是，EIAV gp45的融合后构象尚未确定。 EIAV是慢病毒的第一个成员，已成功开发出有效的疫苗。减毒疫苗株FDDV是由病原株通过驴真皮细胞中的一系列传代而产生的。我们以前曾报道过gp45中的V / I505T突变与gp90中的其他突变相结合可能会潜在地促进疫苗株的成功。为此，我们现在报告来自宽型和疫苗株的gp45蛋白的结构和生化研究，为EIAV疫苗的发展提供了有价值的结构模型。

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