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Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles

机译:多种病毒糖蛋白和CD4共同包装到同一个人免疫缺陷病毒(HIV-1)颗粒中

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摘要

BackgroundRetroviruses can acquire not only their own glycoproteins as they bud from the cellular membrane, but also some cellular and foreign viral glycoproteins. Many of these non-native glycoproteins are actively recruited to budding virions, particularly other viral glycoproteins. This observation suggests that there may be a conserved mechanism underlying the recruitment of glycoproteins into viruses. If a conserved mechanism is used, diverse glycoproteins should localize to a single budding retroviral particle. On the other hand, if viral glycoproteins have divergent mechanisms for recruitment, the different glycoproteins could segregate into different particles.
机译:背景逆转录病毒不仅可以在从细胞膜中发芽时获取自己的糖蛋白,还可以获取一些细胞和外来病毒糖蛋白。这些非天然糖蛋白中的许多积极地募集到萌芽的病毒体,特别是其他病毒糖蛋白。该观察结果表明糖蛋白募集到病毒中可能存在保守的机制。如果使用保守机制,则多种糖蛋白应定位于单个萌芽的逆转录病毒颗粒。另一方面,如果病毒糖蛋白具有不同的募集机制,则不同的糖蛋白可能会分离成不同的颗粒。

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