首页> 美国卫生研究院文献>Retrovirology >Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals

【2h】

Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals

机译：在大多数未经治疗的HIV-1感染个体中均可检测到具有异质中和能力的抗MPER抗体

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundThe MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic environment seems to hamper the elicitation of these antibodies in HIV infected individuals.We have quantified and characterized anti-MPER antibodies by ELISA and by flow cytometry using a collection of mini gp41-derived proteins expressed on the surface of 293T cells. Longitudinal plasma samples from 35 HIV-1 infected individuals were assayed for MPER recognition and MPER-dependent neutralizing capacity using HIV-2 viruses engrafted with HIV-1 MPER sequences.

机译：背景HIV-1包膜糖蛋白gp41的MPER区被广泛中和的抗体靶向。然而，该表位在疏水性环境中的定位似乎阻碍了HIV感染者体内这些抗体的诱导。我们已经通过ELISA和流式细胞术使用了一系列表达于gp41的微型gp41衍生蛋白的定量和表征了抗MPER抗体。 293T细胞的表面。使用嫁接了HIV-1 MPER序列的HIV-2病毒，对35位HIV-1感染者的纵向血浆样本进行了MPER识别和MPER依赖性中和能力的测定。

著录项

期刊名称 Retrovirology
作者
Luis M Molinos-Albert; Jorge Carrillo; Marta Curriu; Maria L Rodriguez de la Concepción; Silvia Marfil; Elisabet García; Bonaventura Clotet; Julià Blanco;
展开▼
作者单位

展开▼
年(卷),期 2014(11),-1
年度 2014
页码 44
总页数 12
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
关键词

相似文献

外文文献
中文文献
专利

1. Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals [J] . Luis M Molinos-Albert, Jorge Carrillo, Marta Curriu, Retrovirology . 2014,第S1期

机译：在大多数未经治疗的HIV-1感染者中均可检测到具有异质中和能力的抗MPER抗体
2. Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women [J] . Mkhize Nonhlanhla N., Durgiah Raveshni, Ashley Vicki, AIDS . 2016,第7期

机译：在感染HIV-1的女性生殖道中检测到的广泛中和抗体特异性
3. Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals [J] . Narayanaiah Cheedarla, K. Lucia Precilla, Hemalatha Babu, Scientific reports. . 2017,第1期

机译：宽且有效的交叉思克中和抗体在HIV-1亚型C感染个体的血浆中具有多种特异性的抗体
4. Bovine viral diarrhea virus transmission from persistently infected cattle to non-persistently infected cattle when commingled: an evaluation of serum neutralizing antibody titers [C] . K.A. Foster, R.A. Hesse, L. Peddireddi, Annual Conference of the American^Association^of^Bovine^Practitioners. . 2014

机译：牛病毒性腹泻病毒从持续受感染的牛在混合时从持续感染的牛：血清中和抗体滴度的评估
5. Two Sides to the Same Antibody: Assessing the Role of Neutralizing and Non-neutralizing Antibodies in Mother-to-child Transmission of HIV-1 [D] . Ghulam-Smith, Melissa 2021

机译：两侧到同一抗体：评估中和和非中和抗体在HIV-1的母儿传播中的作用
6. Examination of sera from human immunodeficiency virus type 1 (HIV-1)-infected individuals for antibodies reactive with peptides corresponding to the principal neutralizing determinant of HIV-1 gp120 and for in vitro neutralizing activity. [O] . R Q Warren, S A Anderson, W M Nkya, 1992

机译：检查人类免疫缺陷病毒1型（HIV-1）感染者的血清是否可与对应于HIV-1 gp120主要中和决定簇的肽发生反应的抗体以及体外中和活性。
7. Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals [O] . Molinos-Albert Luis M., Carrillo Jorge, Curriu Marta, 2014

机译：在大多数未经治疗的HIV-1感染个体中均可检测到具有异质中和能力的抗MPER抗体

Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals

摘要

著录项

相似文献

相关主题

期刊订阅