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首页> 美国卫生研究院文献>Revista do Instituto de Medicina Tropical de So Paulo >MOLECULAR CHARACTERIZATION OF INFLUENZA B VIRUS OUTBREAK ON A CRUISE SHIPIN BRAZIL 2012
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MOLECULAR CHARACTERIZATION OF INFLUENZA B VIRUS OUTBREAK ON A CRUISE SHIPIN BRAZIL 2012

机译：邮轮上流感病毒暴发的分子特性。巴西2012

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摘要

In February 2012, an outbreak of respiratory illness occurred on the cruise ship MSC Armonia in Brazil. A 31-year-old female crew member was hospitalized with respiratory failure and subsequently died. To study the etiology of the respiratory illness, tissue taken at necropsy from the deceased woman and respiratory specimens from thirteen passengers and crew members with respiratory symptoms were analyzed. Influenza real-time RT-PCR assays were performed, and the full-length hemagglutinin (HA) gene of influenza-positive samples was sequenced. Influenza B virus was detected in samples from seven of the individuals, suggesting that it was the cause of this respiratory illness outbreak. The sequence analysis of the HA gene indicated that the virus was closely related to the B/Brisbane/60/2008-like virus, Victoria lineage, a virus contained in the 2011-12 influenza vaccine for the Southern Hemisphere. Since the recommended composition of the influenza vaccine for use during the 2013 season changed, an intensive surveillance of viruses circulating worldwide is crucial. Molecular analysis is an important tool to characterize the pathogen responsible for an outbreak such as this. In addition, laboratory disease surveillance contributes to the control measures for vaccine-preventable influenza.
机译：2012年2月，巴西游轮MSC Armonia上爆发了呼吸道疾病。一名31岁女机组人员因呼吸衰竭住院，随后死亡。为了研究呼吸道疾病的病因，分析了死者尸检时的组织以及来自十三名乘客和机组人员呼吸道症状的呼吸道标本。进行了流感实时RT-PCR测定，并对流感阳性样本的全长血凝素（HA）基因进行了测序。在七个人的样本中检测到乙型流感病毒，这表明这是这种呼吸道疾病暴发的原因。 HA基因的序列分析表明，该病毒与B / Brisbane / 60/2008样病毒，Victoria血统密切相关，该病毒包含在南半球2011-12年流感疫苗中。由于建议在2013赛季使用的流感疫苗的成分发生了变化，因此对全球传播的病毒进行严格监控至关重要。分子分析是表征导致此类疾病爆发的病原体的重要工具。此外，实验室疾病的监测有助于控制疫苗可预防的流感。

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