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首页> 美国卫生研究院文献>Schizophrenia Bulletin >Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity
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Neurobiological Changes of Schizotypy: Evidence From Both Volume-Based Morphometric Analysis and Resting-State Functional Connectivity

机译：精神分裂症的神经生物学变化：从基于体积的形态分析和静止状态功能连接的证据。

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The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire and underwent brain structural and resting-state functional magnetic resonance imaging on a 3T scanner. Voxel-based morphometric analysis and graph theory-based functional network analysis were conducted. Individuals with high schizotypy showed reduced gray matter (GM) density in the insula and the dorsolateral prefrontal gyrus. The graph theoretical analysis showed that individuals with high schizotypy showed similar global properties in their functional networks as low schizotypy individuals. Several hubs of the functional network were identified in both groups, including the insula, the lingual gyrus, the postcentral gyrus, and the rolandic operculum. More hubs in the frontal lobe and fewer hubs in the occipital lobe were identified in individuals with high schizotypy. By comparing the functional connectivity between clusters with abnormal GM density and the whole brain, individuals with high schizotypy showed weaker functional connectivity between the left insula and the putamen, but stronger connectivity between the cerebellum and the medial frontal gyrus. Taken together, our findings suggest that individuals with high schizotypy present changes in terms of GM and resting-state functional connectivity, especially in the frontal lobe.
机译：当前的研究试图通过整合源自大脑结构和功能成像的网络来检查具有高精神分裂症的个体的潜在大脑变化。使用精神分裂症人格问卷对患有高精神分裂症（n = 35）和低精神分裂症（n = 34）对照的个体进行筛查，并在3T扫描仪上进行脑结构和静止状态功能磁共振成像。进行了基于体素的形态分析和基于图论的功能网络分析。精神分裂症患者的个体显示出岛状岛和背外侧前额回中的灰质（GM）密度降低。图理论分析表明，具有高精神分裂症的人在其功能网络中表现出与低精神分裂症的人相似的整体特性。在两组中都确定了功能网络的几个枢纽，包括绝缘岛，舌状回，中央后回和罗兰。在精神分裂症患者中，额叶中的枢纽更多，枕叶中的枢纽更少。通过比较具有异常GM密度的簇与全脑之间的功能连通性，精神分裂症患者显示出左岛岛与壳核之间的功能连通性较弱，而小脑与额额内侧中枢之间的连通性较强。综上所述，我们的研究结果表明，精神分裂症患者的个体在GM和静息状态功能连接性方面表现出变化，尤其是在额叶中。

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