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首页> 美国卫生研究院文献>The Scientific World Journal >Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia
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Auditing Clinical Outcomes after Introducing Off-Licence Prescribing of Atypical Antipsychotic Melperone for Patients with Treatment Refractory Schizophrenia

机译：对难治性精神分裂症患者采用非典型抗精神病药物美仑酮的非处方处方审核后的临床结果

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Aims and Method. To evaluate the practical utility of off-licence prescribing and clinical outcomes of treatment with atypical antipsychotic Melperone. Method: Prospective data collection on patient's clinical characteristics and outcomes. Results. 17 patients with a diagnosis of refractory schizophrenia were identified as suitable for off-license prescribing of Melperone and commenced treatment (13 were previously treated with Clozapine). Seven of those currently remain on Melperone (41%), and for six patents, the BPRS symptom scores reduced significantly over time (24–61%) additionally patients displayed improvements of their quality of life. Six patients were discontinued due to noncompliance and/or side effects. Melperone was ineffective in the other four patients. Clinical Implications. The example of a small group of patients responding well to a comparably safe and inexpensive atypical antipsychotic with favourable side effect profile should encourage clinicians to use this tool as third-line treatment and to conduct more systematic clinical research.
机译：目的和方法。评估非典型抗精神病药物美蓬酮的非处方处方和临床疗效的实用性。方法：收集有关患者临床特征和结果的前瞻性数据。结果。确诊为难治性精神分裂症的17例患者被确定适合许可开立美潘酮并开始治疗（其中13例曾接受氯氮平治疗）。目前有7名患者（41％）仍在使用Melperone，并且对于6项专利，BPRS症状评分随着时间的推移而显着降低（24-61％），另外患者的生活质量得到了改善。由于不依从和/或副作用而中断了六名患者的治疗。在其他四名患者中，Melperone无效。临床意义。少数患者对安全性和价格便宜的非典型抗精神病药物反应良好，副作用良好的例子，应该鼓励临床医生将该工具用作三线治疗并进行更系统的临床研究。

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