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首页> 美国卫生研究院文献>The Scientific World Journal >Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug Carboxyfluorescein: Dependency on Their Composition
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Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug Carboxyfluorescein: Dependency on Their Composition

机译：柔性脂质体对亲水模型药物羧荧光素皮肤沉积的影响：对其组成的依赖

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This study focuses on the effect of different flexible liposomes containing sodium cholate, Tween 80, or cineol on skin deposition of carboxyfluorescein (CF). Size distribution, morphology, zeta potential, and stability of the prepared vesicles were evaluated. The influence of these systems on the skin deposition of CF utilizing rat skin as membrane model was investigated. Results showed that all of the investigated liposomes had almost spherical shapes with low polydispersity (PDI < 0.3) and particles size range from 83 to 175 nm. All liposomal formulations exhibited negative zeta potential, good drug entrapment efficiency, and stability. In vitro skin deposition data showed that flexible liposomes gave significant deposition of CF on the skin compared to conventional liposomes and drug solutions. This study revealed that flexible liposomes, containing cineole, were able to deliver higher amount of CF suggesting that the hydrophilic drugs delivery to the skin was strictly correlated to the vesicle composition.
机译：这项研究的重点是含有胆酸钠，吐温80或电影胶的不同柔性脂质体对羧基荧光素（CF）皮肤沉积的影响。评价了大小分布，形态，ζ电势和所制备的囊泡的稳定性。利用大鼠皮肤作为膜模型研究了这些系统对CF皮肤沉积的影响。结果表明，所有研究的脂质体均具有几乎球形的形状，低多分散性（PDI <0.3），粒径范围为83至175 nm。所有脂质体制剂均表现出负的ζ电势，良好的药物截留效率和稳定性。体外皮肤沉积数据显示，与常规脂质体和药物溶液相比，柔性脂质体可在皮肤上显着沉积CF。这项研究表明，含有桉树脑的柔性脂质体能够递送更高量的CF，这表明亲水性药物向皮肤的递送与囊泡的成分紧密相关。

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