Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

机译：临床应用诱导多能干细胞的产生技术进展

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Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.

机译：通过病毒介导的确定的转录因子转导，将体细胞重编程为诱导性多能干细胞（iPSC）。 iPSC的产生具有巨大的医学意义，因为它们有可能成为患者特异性细胞的来源。为了临床应用的最终目标，必须克服由于病毒DNA整合而导致的低重编程效率和染色体异常的局限性。在本文中，我们总结了用于生成iPSC的重编程技术的现状，并讨论了用于个性化基于细胞的替代疗法开发安全iPSC的潜在方法。

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期刊名称 The Scientific World Journal
作者
Seung-Ick Oh; Chang Kyu Lee; Kyung Jin Cho; Kyung-Ok Lee; Ssang-Goo Cho; Sunghoi Hong;
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年(卷),期 2012(2012),-1
年度 2012
页码 417809
总页数 10
原文格式 PDF
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1. Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications [J] . Seung-IckOh, Chang KyuLee, Kyung JinCho, ScientificWorldJournal . 2012,第3期

机译：临床应用诱导多能干细胞的技术进步
2. Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications [J] . Angela Di Baldassarre, Elisa Cimetta, Sveva Bollini, Cells . 2018,第6期

机译：人诱导多能干细胞技术和心肌细胞的产生：进展和临床应用。
3. Generation and clinical application of human T cell-derived induced pluripotent stem cells [J] . Tomohisa Seki, Shinsuke Yuasa, Keiichi Fukuda Inflammation and regeneration. . 2011,第5期

机译：人T细胞诱导的多能干细胞的产生及其临床应用
4. EFFECTIVE HYPOTHERMIC STORAGE OF HUMAN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES COMPATIBLE WITH GLOBAL DISTRIBUTION OF CELLS FOR CLINICAL APPLICATIONS AND TOXICOLOGY TESTING [C] . Margarida Serra, Claudia Correia, Alexey Koshkin, Scale-up and manufacturing of cell-based therapies V . 2017

机译：有效的人多能干细胞来源的心肌细胞的低温储存与临床应用和毒理学检测的细胞全球分布相适应
5. Generation of Induced Pluripotent Stem Cell Derived Endothelial Cells from Fibrodysplasia Ossificans Progressiva Patients - A Disease Model of ActivinA and BMP-Induced ALK2 Receptor Activation =Generierung von Endothelzellen aus induzierten pluripotenten [D] . Hildebrandt, Susanne. 2020

机译：生成诱导多能干细胞衍生的纤维型胰腺类骨质人进化患者的内皮细胞 - Activina和BMP诱导的Alk2受体激活=普通钨患者的疾病模型= Induzierten ploripotenten
6. Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications [O] . Angela Di Baldassarre, Elisa Cimetta, Sveva Bollini, 2018

机译：人诱导多能干细胞技术和心肌细胞的产生：进展和临床应用。
7. Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications [O] . Oh, Seung-Ick, Lee, Chang Kyu, Cho, Kyung Jin, 2012

机译：临床应用诱导多能干细胞的产生技术进展

Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications

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