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Micro Machining of Injection Mold Inserts for Fluidic Channel of Polymeric Biochips

机译：聚合物生物芯片流体通道注塑模具嵌件的微加工

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摘要

Recently, the polymeric micro-fluidic biochip, often called LOC (lab-on-a-chip), has been focused as a cheap, rapid and simplified method to replace the existing biochemical laboratory works. It becomes possible to form miniaturized lab functionalities on a chip with the development of MEMS technologies. The micro-fluidic chips contain many micro-channels for the flow of sample and reagents, mixing, and detection tasks. Typical substrate materials for the chip are glass and polymers. Typical techniques for microfluidic chip fabrication are utilizing various micro pattern forming methods, such as wet-etching, micro-contact printing, and hot-embossing, micro injection molding, LIGA, and micro powder blasting processes, etc. In this study, to establish the basis of the micro pattern fabrication and mass production of polymeric micro-fluidic chips using injection molding process, micro machining method was applied to form micro-channels on the LOC molds. In the research, a series of machining experiments using micro end-mills were performed to determine optimum machining conditions to improve surface roughness and shape accuracy of designed simplified micro-channels. Obtained conditions were used to machine required mold inserts for micro-channels using micro end-mills. Test injection processes using machined molds and COC polymer were performed, and then the results were investigated.
机译：最近，通常被称为LOC（片上实验室）的聚合物微流体生物芯片已经成为一种廉价，快速和简化的方法，以取代现有的生化实验室工作。随着MEMS技术的发展，有可能在芯片上形成小型化的实验室功能。微流控芯片包含许多微通道，用于样品和试剂的流动，混合和检测任务。芯片的典型基板材料是玻璃和聚合物。微流控芯片制造的典型技术是利用各种微图案形成方法，例如湿法蚀刻，微接触印刷和热压花，微注射成型，LIGA和微粉喷砂工艺等。在本研究中，在微细图形制造和利用注射成型工艺批量生产聚合物微流控芯片的基础上，采用微机械加工方法在LOC模具上形成微通道。在研究中，进行了一系列使用微型立铣刀的加工实验，以确定最佳加工条件，以改善设计的简化微通道的表面粗糙度和形状精度。使用微型立铣刀，将获得的条件用于加工微通道所需的模具嵌件。使用机加工模具和COC聚合物进行测试注射过程，然后研究结果。

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