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首页> 美国卫生研究院文献>Sensors (Basel Switzerland) >Optimization of an Optical Inspection System Based on the Taguchi Method for Quantitative Analysis of Point-of-Care Testing
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Optimization of an Optical Inspection System Based on the Taguchi Method for Quantitative Analysis of Point-of-Care Testing

机译：基于Taguchi方法的光学检查系统的现场护理定量分析的优化

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摘要

This study presents an optical inspection system for detecting a commercial point-of-care testing product and a new detection model covering from qualitative to quantitative analysis. Human chorionic gonadotropin (hCG) strips (cut-off value of the hCG commercial product is 25 mIU/mL) were the detection target in our study. We used a complementary metal-oxide semiconductor (CMOS) sensor to detect the colors of the test line and control line in the specific strips and to reduce the observation errors by the naked eye. To achieve better linearity between the grayscale and the concentration, and to decrease the standard deviation (increase the signal to noise ratio, S/N), the Taguchi method was used to find the optimal parameters for the optical inspection system. The pregnancy test used the principles of the lateral flow immunoassay, and the colors of the test and control line were caused by the gold nanoparticles. Because of the sandwich immunoassay model, the color of the gold nanoparticles in the test line was darkened by increasing the hCG concentration. As the results reveal, the S/N increased from 43.48 dB to 53.38 dB, and the hCG concentration detection increased from 6.25 to 50 mIU/mL with a standard deviation of less than 10%. With the optimal parameters to decrease the detection limit and to increase the linearity determined by the Taguchi method, the optical inspection system can be applied to various commercial rapid tests for the detection of ketamine, troponin I, and fatty acid binding protein (FABP).
机译：这项研究提出了一种用于检测商业即时检验产品的光学检测系统，以及一种涵盖了从定性到定量分析的新型检测模型。人类绒毛膜促性腺激素（hCG）条（hCG商业产品的临界值为25 mIU / mL）是我们研究的检测目标。我们使用互补金属氧化物半导体（CMOS）传感器检测特定条带中测试线和控制线的颜色，并减少肉眼观察的误差。为了获得更好的灰度和浓度之间的线性关系，并减少标准偏差（增加信噪比，S / N），Taguchi方法被用来为光学检测系统找到最佳参数。妊娠试验采用侧向免疫测定的原理，试验和对照线的颜色由金纳米颗粒引起。由于采用了夹心免疫分析模型，通过增加hCG浓度，测试线中金纳米颗粒的颜色变暗。结果表明，信噪比从43.48 dB增加到53.38 dB，hCG浓度检测从6.25上升到50 mIU / mL，标准偏差小于10％。借助减少Taguchi方法确定的检测限和增加线性的最佳参数，光学检测系统可应用于各种商业快速检测中，用于检测氯胺酮，肌钙蛋白I和脂肪酸结合蛋白（FABP）。

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