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Optical Micro/Nanofiber-Based Localized Surface Plasmon Resonance Biosensors: Fiber Diameter Dependence

机译:基于光学微/纳米纤维的局域表面等离子体共振生物传感器:纤维直径的依赖。

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摘要

Integration of functional nanomaterials with optical microanofibers (OMNFs) can bring about novel optical properties and provide a versatile platform for various sensing applications. OMNFs as the key element, however, have seldom been investigated. Here, we focus on the optimization of fiber diameter by taking microanofiber-based localized surface plasmon resonance sensors as a model. We systematically study the dependence of fiber diameter on the sensing performance of such sensors. Both theoretical and experimental results show that, by reducing fiber diameter, the refractive index sensitivity can be significantly increased. Then, we demonstrate the biosensing capability of the optimized sensor for streptavidin detection and achieve a detection limit of 1 pg/mL. Furthermore, the proposed theoretical model is applicable to other nanomaterials and OMNF-based sensing schemes for performance optimization.
机译:功能纳米材料与光学微/纳米纤维(OMNF)的集成可以带来新颖的光学特性,并为各种传感应用提供多功能平台。然而,很少研究以OMNFs作为关键要素。在这里,我们将重点放在通过基于微/纳米纤维的局部表面等离振子共振传感器作为模型的纤维直径的优化上。我们系统地研究了纤维直径对这种传感器的传感性能的依赖性。理论和实验结果均表明,通过减小纤维直径,可以显着提高折射率灵敏度。然后,我们证明了链霉亲和素检测的最佳传感器的生物传感能力,并达到了1 pg / mL的检测限。此外,提出的理论模型适用于其他纳米材料和基于OMNF的传感方案,以优化性能。

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