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首页> 美国卫生研究院文献>Sensors (Basel Switzerland) >Application of Near-Infrared Optical Feedback Cavity Enhanced Absorption Spectroscopy (OF-CEAS) to the Detection of Ammonia in Exhaled Human Breath
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Application of Near-Infrared Optical Feedback Cavity Enhanced Absorption Spectroscopy (OF-CEAS) to the Detection of Ammonia in Exhaled Human Breath

机译：近红外光反馈腔增强吸收光谱法（OF-CEAS）在呼出气中氨气检测中的应用

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The qualitative and quantitative analysis to trace gas in exhaled human breath has become a promising technique in biomedical applications such as disease diagnosis and health status monitoring. This paper describes an application of a high spectral resolution optical feedback cavity enhanced absorption spectroscopy (OF-CEAS) for ammonia detection in exhaled human breath, and the main interference of gases such as CO2 and H2O are approximately eliminated at the same time. With appropriate optical feedback, a fibered distributed feedback (DFB) diode laser emitting at 1531.6 nm is locked to the resonance of a V-shaped cavity with a free spectral range (FSR) of 300 MHz and a finesse of 14,610. A minimum detectable absorption coefficient of αmin = 2.3 × 10−9 cm−1 is achieved in a single scan within 5 s, yielding a detection limit of 17 ppb for NH3 in breath gas at low pressure, and this stable system allows the detection limit down to 4.5 ppb when the spectra to be averaged over 16 laser scans. Different from typical CEAS with a static cavity, which is limited by the FSR in frequency space, the attainable spectral resolution of our experimental setup can be up to 0.002 cm−1 owing to the simultaneous laser frequency tuning and cavity dither. Hence, the absorption line profile is more accurate, which is most suitable for low-pressure trace gas detection. This work has great potential for accurate selectivity and high sensitivity applications in human breath analysis and atmosphere sciences.
机译：对呼出气体中痕量气体进行定性和定量分析已成为生物医学应用中的一种有前途的技术，例如疾病诊断和健康状况监测。本文介绍了高光谱分辨率光反馈腔增强吸收光谱（OF-CEAS）在呼出的人类呼吸中氨气检测中的应用，并且几乎同时消除了诸如CO2和H2O等气体的主要干扰。通过适当的光反馈，在1531.6 nm处发射的光纤分布式反馈（DFB）二极管激光器被锁定到V形腔的共振，其自由光谱范围（FSR）为300 MHz，精细度为14,610。在5 s内的单次扫描中获得的最小可检测吸收系数为αmin= 2.3×10 −9 cm -1 ，在NH3中的检测限为17 ppb。在16次激光扫描中对光谱进行平均时，这种稳定的系统可使检测极限降至4.5 ppb。与典型的带有静腔的CEAS（受频率空间中的FSR限制）不同，由于同时进行激光频率调谐和同步，我们的实验装置可获得的光谱分辨率可高达0.002 cm -1 腔抖动。因此，吸收线轮廓更为精确，最适合于低压痕量气体检测。这项工作对于在人类呼吸分析和大气科学中的准确选择性和高灵敏度应用具有巨大潜力。

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