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Characterization of Nucleobases in Broadband Terahertz Spectra from 0.5 to 10 THz with the Air-Biased-Coherent-Detection Technique

机译:空气偏置相干检测技术表征0.5太赫兹至10太赫兹宽带太赫兹光谱中的核糖核酸酶

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摘要

Terahertz time-domain spectroscopy (THz-TDS) is an effective coherent detection technique for deeply understanding the structures and functions of biomolecules. However, generally not full information in the whole THz range can be obtained due to the limited detection bandwidth (usually less than 5 THz) of the traditional THz-TDS systems. In this paper, effective THz absorption spectra in 0.5–10 THz range of five typical nucleobases of DNA/RNA are characterized with a super broadband THz detection technique, called the air-biased- coherent-detection (THz-ABCD) technique. Few unexpected characteristic absorption peaks appeared in the low-frequency region and meanwhile a series of anticipated characteristic absorption peaks are found in the high-frequency region. The fingerprint spectra of these nucleobases are helpful for further analysis on the vibration and twisting behavior of hydrogen bonds, van der Waals and electrostatic forces etc. between and within DNA/RNA biomolecules.
机译:太赫兹时域光谱(THz-TDS)是一种有效的相干检测技术,可用于深入了解生物分子的结构和功能。但是,由于传统THz-TDS系统的检测带宽有限(通常小于5 THz),因此通常无法获得整个THz范围内的全部信息。在本文中,使用超宽带太赫兹检测技术(称为空气偏置相干检测(THz-ABCD)技术)表征了五个典型DNA / RNA核碱基在0.5–10 THz范围内的有效太赫兹吸收光谱。在低频区域很少出现意料之外的特征吸收峰,而在高频区域则发现了一系列预期的特征吸收峰。这些核碱基的指纹图谱有助于进一步分析DNA / RNA生物分子之间和内部的氢键,范德华力和静电力等的振动和扭曲行为。

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