首页> 美国卫生研究院文献>Stem Cell Research Therapy >Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor κB pathway
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Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor κB pathway

机译:脂多糖通过Toll样受体4介导的核因子κB途径差异性影响牙周膜干细胞和骨髓间充质干细胞的成骨分化

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摘要

IntroductionPeriodontitis is initiated and sustained by bacteria. However, the mechanism of bacteria induced periodontitis is still unknown. We hypothesized that bacterial components can affect the functions of stem cells in the periodontium. In this study, we comparatively investigated the influence of Lipopolysaccharide (LPS) on the osteogenesis potential of human periodontal ligament stem cells (PDLSCs) and bone marrow mesenchymal stem cells (BMMSCs).
机译:引言牙周炎是由细菌引发并持续的。然而,细菌诱发牙周炎的机制仍是未知的。我们假设细菌成分会影响牙周干细胞的功能。在这项研究中,我们比较研究了脂多糖(LPS)对人牙周膜干细胞(PDLSCs)和骨髓间充质干细胞(BMMSCs)成骨潜能的影响。

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