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Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw

机译:间充质干细胞之间的相互作用治疗下颌骨药物性坏死

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摘要

BackgroundMesenchymal stem cells (MSCs) have been isolated from a variety of tissues, including bone marrow, adipose, and mucosa. MSCs have the capacity for self-renewal and differentiation. Reports have been published on the systemic administration of MSCs leading to functional improvements by engraftment and differentiation, thus providing a new strategy to regenerate damaged tissues. Recently, it has become clear that MSCs possess immunomodulatory properties and can therefore be used to treat diseases. However, the therapeutic effect mechanisms of MSCs are yet to be determined. Here, we investigated these mechanisms using a medication-related osteonecrosis of the jaw (MRONJ)-like mouse model.
机译:背景已经从包括骨髓,脂肪和粘膜在内的多种组织中分离出间充质干细胞(MSC)。 MSC具有自我更新和分化的能力。关于MSCs的系统管理的报告已经发表,通过植入和分化导致功能改善,从而提供了再生受损组织的新策略。最近,已经清楚的是,MSC具有免疫调节特性,因此可以用于治疗疾病。但是,MSC的治疗作用机制尚未确定。在这里,我们使用与药物相关的颌骨坏死(MRONJ)小鼠模型研究了这些机制。

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