首页> 美国卫生研究院文献>Toxicology Reports >Further development of mathematical description for combined toxicity: A case study of lead–fluoride combination
【2h】

Further development of mathematical description for combined toxicity: A case study of lead–fluoride combination

机译:组合毒性数学描述的进一步发展:以氟化铅-铅组合为例

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

In this article, we check and develop further some postulates of the theory and mathematical modeling of combined toxic effect that we proposed earlier . To this end, we have analyzed the results of an experiment on rats exposed during 6 weeks to repeated intraperitoneal injections of lead acetate, sodium fluoride or both. The development of intoxication was estimated quantitatively with 54 functional, biochemical and morphometric indices. For mathematical description of the effect that lead and fluorine doses produced alone or in combination, we used a response surface regression model containing linear and cross terms (hyperbolic paraboloid). It is shown that the combination of lead and fluoride features the same 10 types of combined effect that we found previously for the lead and cadmium combination. Special attention is given to indices on which lead and fluorine produce an opposite effect.
机译:在本文中,我们检查并进一步开发了我们先前提出的联合毒性效应的理论和数学模型的一些假设。为此,我们分析了大鼠在6周内反复腹膜内注射乙酸铅,氟化钠或两者的实验结果。用54个功能,生化和形态计量指标定量评估了中毒的发生。对于铅或氟单独或组合产生的影响的数学描述,我们使用了包含线性和交叉项(双曲线抛物面)的响应面回归模型。结果表明,铅和氟化物的组合具有与我们先前发现的铅和镉组合相同的10种组合效应。要特别注意铅和氟产生相反作用的指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号