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Focus: 50 Years of DNA Repair: The Yale SymposiumReports: Early Days of DNA Repair: Discovery of Nucleotide Excision Repair andHomology-Dependent Recombinational Repair

机译：焦点：DNA修复50年：耶鲁研讨会报告：DNA修复的早期：发现核苷酸切除修复和依赖同源性的重组修复

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The discovery of nucleotide excision repair in 1964 showed that DNA could be repaired by a mechanism that removed the damaged section of a strand and replaced it accurately by using the remaining intact strand as the template. This result showed that DNA could be actively metabolized in a process that had no precedent. In 1968, experiments describing postreplication repair, a process dependent on homologous recombination, were reported. The authors of these papers were either at Yale University or had prior Yale connections. Here we recount some of the events leading to these discoveries and consider the impact on further research at Yale and elsewhere.

机译：1964年核苷酸切除修复的发现表明，可以用一种机制修复DNA，该机制可以去除链的受损部分，并使用剩余的完整链作为模板准确地替换它。该结果表明DNA可以在没有先例的过程中被积极地代谢。 1968年，报道了描述复制后修复的实验，该过程依赖于同源重组。这些论文的作者要么在耶鲁大学就读，要么与耶鲁大学有过往来。在这里，我们叙述导致这些发现的一些事件，并考虑对耶鲁大学和其他地方的进一步研究的影响。

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期刊名称 The Yale Journal of Biology and Medicine
作者
W. Dean Rupp;
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作者单位

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年(卷),期 2013(86),4
年度 2013
页码 499–505
总页数 7
原文格式 PDF
正文语种
中图分类生物学;
关键词
DNA repair homology-dependent repair leading strand restart nucleotide excision repair Yale Radiobiology recombination recombinational repair;

机译：DNA修复;同源性依赖修复;前导链重启;核苷酸切除修复;耶鲁大学放射生物学;重组;重组修复;

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专利

1. DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells [J] . Seisuke Kimura, Yasue Tahira, Toyotaka Ishibashi, Nucleic Acids Research . 2004,第9期

机译：高等植物的DNA修复;光活化是非增殖细胞中主要的DNA修复途径，而切除修复（核苷酸切除修复和碱基切除修复）在增殖细胞中活跃
2. DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non‐proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells [J] . Junji Hashimoto, Kengo Sakaguchi, Seisuke Kimura, Nucleic acids research . 2004,第9期

机译：高等植物的DNA修复;光活化是非增殖细胞的主要DNA修复途径，而切除修复（核苷酸切除修复和碱基切除修复）在增殖细胞中活跃
3. DNA damage formation, DNA repair, and survival after exposure of DNA repair-proficient and nucleotide excision repair-deficient human lymphoblasts to UVA1 and UVB. [J] . Runger TM, Moller K, Jung T, International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations . 2000,第6期

机译：DNA修复能力强和核苷酸切除修复缺陷的人淋巴母细胞暴露于UVA1和UVB后，DNA损伤的形成，DNA修复和存活。
4. The mechanism of base-excision DNA repair by Endonuclease-VIII as revealed from its trapped covalent intermediate with a DNA substrate [C] . Gali Golan, Dmitry O.Zharkov, Rotem Gilboa International Peptide Symposium;European Peptide Symposium . 2005

机译：通过与DNA底物的被捕获的共价中间体揭示的内切核酸酶-VIII碱基切除DNA修复机制
5. Multiple DNA binding domains mediate the function of ERCC1-XPF in nucleotide excision repair and interstrand crosslink repair. [D] . Su, Yan. 2012

机译：多个DNA结合域介导ERCC1-XPF在核苷酸切除修复和链间交联修复中的功能。
6. Focus: 50 Years of DNA Repair: The Yale SymposiumReports: The Awakening of DNA Repair at Yale [O] . Philip C. Hanawalt 2013

机译：焦点：DNA修复50年：耶鲁研讨会报告：耶鲁大学DNA修复的唤醒
7. Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome. [O] . Habraken, Y, Sung, P, Prakash, S, 1996

机译：转录因子TFIIH和DNA核酸内切酶Rad2构成酵母核苷酸切除修复因子3：对核苷酸切除修复和Cockayne综合征的影响。

Focus: 50 Years of DNA Repair: The Yale SymposiumReports: Early Days of DNA Repair: Discovery of Nucleotide Excision Repair andHomology-Dependent Recombinational Repair

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