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首页> 美国卫生研究院文献>The World Journal of Mens Health >Traditional Chinese Medicine as a Remedy for Male Infertility: A Review
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Traditional Chinese Medicine as a Remedy for Male Infertility: A Review

机译：中医药作为男性不育症的一种治疗方法

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摘要

Male infertility (MI) is a complex multifactorial disease, and idiopathic infertility accounts for 30% of cases of MI. At present, the evidence for the effectiveness of empirical drugs is limited, and in vitro fertilization is costly and may increase the risk of birth defects and childhood cancers. Therefore, affected individuals may feel obliged to pursue natural remedies. Traditional Chinese medicine (TCM) may represent a useful option for infertile men. It has been demonstrated that TCM can regulate the hypothalamic-pituitary-testicular axis and boost the function of Sertoli cells and Leydig cells. TCM can also alleviate inflammation, prevent oxidative stress, reduce the DNA fragmentation index, and modulate the proliferation and apoptosis of germ cells. Furthermore, TCM can supply trace elements and vitamins, ameliorate the microcirculation of the testis, decrease the levels of serum anti-sperm antibody, and modify epigenetic markers. However, the evidence in favor of TCM is not compelling, which has hindered the development of TCM. This review attempts to elucidate the underlying therapeutic mechanisms of TCM. We also explore the advantages of TCM, differences between TCM and Western medicine, and problems in existing studies. Subsequently, we propose solutions to these problems and present perspectives for the future development of TCM.
机译：男性不育（MI）是一种复杂的多因素疾病，特发性不育占MI病例的30％。目前，经验药物有效性的证据有限，体外受精成本高昂，并可能增加出生缺陷和儿童癌症的风险。因此，受影响的个人可能有义务寻求自然疗法。中医（TCM）对于不育男性可能是一种有用的选择。已经证明，中药可以调节下丘脑-垂体-睾丸轴并增强Sertoli细胞和Leydig细胞的功能。中医还可以减轻炎症，预防氧化应激，降低DNA断裂指数，调节生殖细胞的增殖和凋亡。此外，中药可以提供微量元素和维生素，改善睾丸的微循环，降低血清抗精子抗体的水平，并修饰表观遗传标记。然而，支持中医的证据并不令人信服，这阻碍了中医的发展。这篇综述试图阐明中医的潜在治疗机制。我们还将探讨中医药的优势，中西医学的差异以及现有研究中存在的问题。随后，我们针对这些问题提出了解决方案，并提出了中医药未来发展的前景。

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