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首页> 美国卫生研究院文献>Veterinary Medicine International >Hemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C
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Hemotoxicity Induced by Chronic Chlorpyrifos Exposure in Wistar Rats: Mitigating Effect of Vitamin C

机译：Wistar大鼠慢性毒死rif暴露引起的血液毒性：缓解维生素C的作用

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The study evaluated the ameliorative effect of vitamin C on chronic chlorpyrifos-induced hematological alterations in Wistar rats. Twenty adult male rats divided into 4 groups of 5 animals each were exposed to the following regimens: group I (S/oil) was administered soya oil (2 mL/kg b.w.), while group II (VC) was given vitamin C (100 mg/kg b.w.); group III was dosed with CPF (10.6 mg/kg b.w.); group IV was pretreated with vitamin C (100 mg/kg) and then exposed to CPF (10.6 mg/kg b.w.), 30 minutes later. The regimens were administered by oral gavage once daily for a period of 17 weeks. Blood samples collected at the end of the study revealed reduction in the levels of pack cell volume, hemoglobin, red blood cells, leukocytes (attributed to neutropenia, lymphopenia, and monocytopenia), and platelets in the CPF group, which were ameliorated in the vitamin C- pretreated group. The elevated values of malonaldehyde, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and neutrophil/lymphocyte ratio in the CPF group were restored in those pretreated with vitamin C. The study has shown that chronic CPF-induced adversity on hematological parameters of Wistar rats was mitigated by pretreatment with vitamin C.
机译：该研究评估了维生素C对Wistar大鼠慢性毒死rif引起的血液学改变的改善作用。将20只成年雄性大鼠分为4组，每组5只动物，分别接受以下治疗方案：第I组（S /油）施用大豆油（2毫升/千克体重），而第II组（VC）给予维生素C（100毫克）毫克/千克体重）;第三组给予CPF（10.6μg/ kg b.w.）；第IV组用维生素C（100μg/ kg）预处理，然后在30分钟后暴露于CPF（10.6μg/ kg b.w.）。每天一次通过管饲法给药方案，持续17周。研究结束时采集的血液样本显示，CPF组的包装细胞体积，血红蛋白，红细胞，白细胞（归因于中性粒细胞减少，淋巴细胞减少和单核细胞减少症）和血小板减少，维生素C改善了C预处理组。维生素C预处理的CPF组中丙二醛，平均红细胞体积，平均红细胞血红蛋白，平均红细胞血红蛋白浓度和中性白细胞/淋巴细胞比值的升高得以恢复。研究表明，慢性CPF引起的血液学指标逆境用维生素C预处理可减轻Wistar大鼠的体重。

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